Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. - Wikidata - wikimedia - TriplyDB

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.

http://www.wikidata.org/entity/Q34627568

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Human genetics and genomics a decade after the release of the draft sequence of the human genome The epigenetic landscape of acute myeloid leukemia The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes Genetic and epigenetic mechanisms in the development of arteriovenous malformations in the brain Epigenetic regulators and their impact on therapy in acute myeloid leukemia Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications Genomics-based Approach and Prognostic Stratification Significance of Gene Mutations in Intermediate-risk Acute Myeloid Leukemia Pediatric AML: From Biology to Clinical Management Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation Epigenomics of cancer - emerging new concepts New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells Mechanisms of epigenetic regulation of leukemia onset and progression Three-stage quality control strategies for DNA re-sequencing data Myeloid malignancies: mutations, models and management Emerging patterns of somatic mutations in cancer The de novo DNA methyltransferase DNMT3A in development and cancer DNA methylation changes in epithelial ovarian cancer histotypes.Next generation sequencing of acute myeloid leukemia: influencing prognosis.Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia.Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations Minimal Residual Disease in Acute Myeloid Leukemia of Adults: Determination, Prognostic Impact and Clinical Applications DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders DNA methylation, its mediators and genome integrity DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia Detectable clonal mosaicism from birth to old age and its relationship to cancer Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling Expression level and immunolocalization of de novo methyltransferase 3 protein (TuDNMT3) in adult females and males of the two-spotted spider mite, Tetranychus urticae.The mutational landscape of chromatin regulatory factors across 4,623 tumor samples.ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons Identification of novel point mutations in splicing sites integrating whole-exome and RNA-seq data in myeloproliferative diseases cnvCapSeq: detecting copy number variation in long-range targeted resequencing data.An NGS Workflow Blueprint for DNA Sequencing Data and Its Application in Individualized Molecular Oncology.

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.

http://www.wikidata.org/entity/Q34627568

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Nature Genetics

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Exome sequencing identifies so ...... A in acute monocytic leukemia.

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Chun-Ming Pan

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Gang Lu

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Huai-Dong Song

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Jian-Qing Mi

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Jie Xu

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Jing-Yi Shi

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Ke-Qin Li

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Lin Tang

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Sai-Juan Chen

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Wen-Xue Liang

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P2860

Cloning, expression and chromosome locations of the human DNMT3 gene family

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

A small-cell lung cancer genome with complex signatures of tobacco exposure

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

Recurring mutations found by sequencing an acute myeloid leukemia genome

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309-315

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10.1038/NG.788

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4

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21399634

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