Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer. - Wikidata - wikimedia - TriplyDB

Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

http://www.wikidata.org/entity/Q34637940

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Mass Spectrometry-Based Proteomics for Investigating DNA Damage-Associated Protein Ubiquitylation Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer Quantifying ubiquitin signaling Systematic approaches to identify E3 ligase substrates The importance of non-nuclear AR signaling in prostate cancer progression and therapeutic resistance Dysregulation of ubiquitin ligases in cancer Comprehensive assessment of cancer missense mutation clustering in protein structures The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.Exploiting Epigenetic Alterations in Prostate Cancer.Roles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications.Application of quantitative proteomics to the integrated analysis of the ubiquitylated and global proteomes of xenograft tumor tissues SPOP mutation leads to genomic instability in prostate cancer.SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase Precision Medicine for Molecularly Targeted Agents and Immunotherapies in Early-Phase Clinical Trials.Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Cancer Types Using a Structural Genomics-based Approach Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.Speckle-type POZ (pox virus and zinc finger protein) protein gene deletion in ovarian cancer: Fluorescence in situ hybridization analysis of a tissue microarray Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression.SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancer Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.Implications of ubiquitin ligases in castration-resistant prostate cancer.RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking.The genomic evolution of human prostate cancer.New advances in genitourinary cancer: evidence gathered in 2014.Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.Molecular subtyping of prostate cancer.Clinical variability and molecular heterogeneity in prostate cancer.SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.Somatic Mutations in Prostate Cancer: Closer to Personalized Medicine.Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer.

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P2860

Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

http://www.wikidata.org/entity/Q34637940

description

2014 nî lūn-bûn

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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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SCIENCE.1250255

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Prostate cancer. Ubiquitylome ...... n SPOP-mutant prostate cancer.

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Anna C Groner

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Holger Moch

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Jean-Philippe P Theurillat

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Marius Pop

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Mirjam Blattner

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Namrata D Udeshi

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Peter J Wild

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Steven A Carr

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Sylvan C Baca

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Tanya Svinkina

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P2860

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells

Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase

Trim24 targets endogenous p53 for degradation

SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

Non-canonical ubiquitin-based signals for proteasomal degradation

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP

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10.1126/SCIENCE.1250255

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6205

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346

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Gilbert G Privé

Levi A Garraway

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2014-10-02T00:00:00Z

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25278611

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