Individual differences in initial sensitivity and acute tolerance predict patterns of chronic drug tolerance to nitrous-oxide-induced hypothermia in rats.
about
Predicting addictive vulnerability: individual differences in initial responding to a drug's pharmacological effectsClarifying the roles of homeostasis and allostasis in physiological regulation.Nitrous oxide causes a regulated hypothermia: rats select a cooler ambient temperature while becoming hypothermic.Repeated nitrous oxide exposure in rats causes a thermoregulatory sign-reversal with concurrent activation of opposing thermoregulatory effectors.Drug-induced regulatory overcompensation has motivational consequences: Implications for homeostatic and allostatic models of drug addiction.Persistence of a hyperthermic sign-reversal during nitrous oxide inhalation despite cue-exposure treatment with and without a drug-onset cue.Robust thermoregulatory overcompensation, rather than tolerance, develops with serial administrations of 70% nitrous oxide to rats.Direct animal calorimetry, the underused gold standard for quantifying the fire of life.Plasma corticosterone, epinephrine, and norepinephrine levels increase during administration of nitrous oxide in rats.Concentration-related metabolic rate and behavioral thermoregulatory adaptations to serial administrations of nitrous oxide in rats.
P2860
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P2860
Individual differences in initial sensitivity and acute tolerance predict patterns of chronic drug tolerance to nitrous-oxide-induced hypothermia in rats.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Individual differences in init ...... e-induced hypothermia in rats.
@ast
Individual differences in init ...... e-induced hypothermia in rats.
@en
Individual differences in init ...... e-induced hypothermia in rats.
@nl
type
label
Individual differences in init ...... e-induced hypothermia in rats.
@ast
Individual differences in init ...... e-induced hypothermia in rats.
@en
Individual differences in init ...... e-induced hypothermia in rats.
@nl
prefLabel
Individual differences in init ...... e-induced hypothermia in rats.
@ast
Individual differences in init ...... e-induced hypothermia in rats.
@en
Individual differences in init ...... e-induced hypothermia in rats.
@nl
P2093
P2860
P1433
P1476
Individual differences in init ...... e-induced hypothermia in rats.
@en
P2093
Brian G Leroux
Douglas S Ramsay
Karl J Kaiyala
Stephen C Woods
P2860
P2888
P356
10.1007/S00213-005-2219-1
P577
2005-08-01T00:00:00Z
P5875
P6179
1047020153