Defective regulatory and effector T cell functions in patients with FOXP3 mutations. - Wikidata - wikimedia - TriplyDB

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

http://www.wikidata.org/entity/Q34648860

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IPEX as a result of mutations in FOXP3 Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells The role of the CD58 locus in multiple sclerosis Inducing and Administering Tregs to Treat Human Disease FOXP3: genetic and epigenetic implications for autoimmunity Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells Flow Cytometry, a Versatile Tool for Diagnosis and Monitoring of Primary Immunodeficiencies Genetics, pathogenesis and clinical interventions in type 1 diabetes Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin AAV2/8-humanFOXP3 gene therapy shows robust anti-atherosclerosis efficacy in LDLR-KO mice on high cholesterol diet A remarkable depletion of both naïve CD4+ and CD8+ with high proportion of memory T cells in an IPEX infant with a FOXP3 mutation in the forkhead domain.Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish Mechanisms of inflammatory responses in obese adipose tissue.Immunologic endocrine disorders.Regulatory T Cells in Allergy and Asthma.Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis Immune phenotype predicts risk for posttransplantation squamous cell carcinoma.Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis.Helminths in the gastrointestinal tract as modulators of immunity and pathology.T regulatory cells are markers of disease activity in multiple sclerosis patients Regulatory T cells and their roles in immune dysregulation and allergy.Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus.From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation.FOXP3, CBLB and ITCH gene expression and cytotoxic T lymphocyte antigen 4 expression on CD4(+) CD25(high) T cells in multiple sclerosis.Exome sequencing identifies a novel FOXP3 mutation in a 2-generation family with inflammatory bowel disease.Relevance of commensal microbiota in the treatment and prevention of inflammatory bowel disease.Autoantibodies to harmonin and villin are diagnostic markers in children with IPEX syndrome.Early short-term antiretroviral therapy is associated with a reduced prevalence of CD8(+)FoxP3(+) T cells in simian immunodeficiency virus-infected controller rhesus macaques.Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth.CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX.Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells Gene/cell therapy approaches for Immune Dysregulation Polyendocrinopathy Enteropathy X-linked syndrome.CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3 Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome.

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Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

http://www.wikidata.org/entity/Q34648860

description

2006 nî lūn-bûn

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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2006 թվականի հունիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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name

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@ast

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@en

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@nl

type

label

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@ast

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@en

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@nl

prefLabel

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@ast

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@en

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

@nl

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Journal of Clinical Investigation

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Defective regulatory and effector T cell functions in patients with FOXP3 mutations

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Anita Lawitschka

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Claudia Sartirana

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Franca Dagna-Bricarelli

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Lucia Perroni

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Megan K Levings

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Minyue Dai

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Rosa Bacchetta

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Sarah E Allan

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Steven F Ziegler

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Susanne Matthes-Martin

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P2860

Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation

Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

Control of regulatory T cell development by the transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

How defects in central tolerance impinge on a deficiency in regulatory T cells

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10.1172/JCI25112

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6

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116

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Laura Passerini

Eleonora Gambineri

Maria Grazia Roncarolo

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16741580

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