Depletion of antibiotic targets has widely varying effects on growth - Wikidata - wikimedia - TriplyDB

Depletion of antibiotic targets has widely varying effects on growth

Depletion of antibiotic targets has widely varying effects on growth

http://www.wikidata.org/entity/Q34651942

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The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Tuberculosis drug discovery in the post-post-genomic era Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria New insights into TB physiology suggest untapped therapeutic opportunities Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity 4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis An IPTG Inducible Conditional Expression System for Mycobacteria An ancient riboswitch class in bacteria regulates purine biosynthesis and one-carbon metabolism Emerging Approaches to Tuberculosis Drug Development: At Home in the Metabolome.Fusing dual-event data sets for Mycobacterium tuberculosis machine learning models and their evaluation.Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis Mycobacterial Esx-3 requires multiple components for iron acquisition.Subpolar addition of new cell wall is directed by DivIVA in mycobacteria.The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening Regulated Expression Systems for Mycobacteria and Their Applications Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors Mycobacterium tuberculosis metabolism Tunable protein degradation in bacteria.Opposing effects of target overexpression reveal drug mechanisms Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria The tuberculosis drug discovery and development pipeline and emerging drug targets.Genetic Approaches to Facilitate Antibacterial Drug Development.Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis Antibiotic resistance: a physicist's view.Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system.A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis.Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance.Genomic tools to profile antibiotic mode of action.Tuberculosis drug discovery and emerging targets.

P2860

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P2860

Depletion of antibiotic targets has widely varying effects on growth

http://www.wikidata.org/entity/Q34651942

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Depletion of antibiotic targets has widely varying effects on growth

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Depletion of antibiotic targets has widely varying effects on growth

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Depletion of antibiotic targets has widely varying effects on growth

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type

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Depletion of antibiotic targets has widely varying effects on growth

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Depletion of antibiotic targets has widely varying effects on growth

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Depletion of antibiotic targets has widely varying effects on growth

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Depletion of antibiotic targets has widely varying effects on growth

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Depletion of antibiotic targets has widely varying effects on growth

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Depletion of antibiotic targets has widely varying effects on growth

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Proceedings of the National Academy of Sciences of the United States of America

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Depletion of antibiotic targets has widely varying effects on growth

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P2093

Christopher M Sassetti

http://www.w3.org/2001/XMLSchema#string

Dirk Schnappinger

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Jee-Hyun Kim

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Jun-Rong Wei

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Kenan Murphy

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Kyu Y Rhee

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Tom Alber

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Vidhya Krishnamoorthy

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P2860

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

Genes required for mycobacterial growth defined by high density mutagenesis

A common mechanism of cellular death induced by bactericidal antibiotics

Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis

Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Antibiotics for emerging pathogens

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

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