Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.
about
Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 proteinRole of calcium in polycystic kidney disease: From signaling to pathologyRole of the Polycystins in Cell Migration, Polarity, and Tissue MorphogenesisPhysiological mechanisms and therapeutic potential of bone mechanosensing.Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion.Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration.Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic diseaseA novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation.Receptor protein tyrosine phosphatases are novel components of a polycystin complexPolycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway.Transgenic overexpression of Anks6(p.R823W) causes polycystic kidney disease in rats.Polycystin-1, 2, and STIM1 interact with IP(3)R to modulate ER Ca release through the PI3K/Akt pathwayPolycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein StabilityDose-dependent effects of sirolimus on mTOR signaling and polycystic kidney diseaseThe isolated polycystin-1 COOH-terminal can activate or block polycystin-1 signaling.G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.Hyperproliferation of PKD1 cystic cells is induced by insulin-like growth factor-1 activation of the Ras/Raf signalling system.Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1.TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulumHeterotrimeric G protein signaling in polycystic kidney diseaseEmerging evidence of a link between the polycystins and the mTOR pathways.Polycystic kidney disease: pathogenesis and potential therapies.Mammalian target of rapamycin and the kidney. II. Pathophysiology and therapeutic implications.Polycystins and cellular Ca2+ signaling.Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD).Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells.Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathwayIdentification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis.Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.Pathways, perspectives and pursuits in polycystic kidney disease.Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling.Modeling Renal Disease "On the Fly".
P2860
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P2860
Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@ast
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@en
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@nl
type
label
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@ast
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@en
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@nl
prefLabel
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@ast
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@en
Polycystin-1 induces resistanc ...... -kinase/Akt signaling pathway.
@nl
P2093
P2860
P356
P1476
Polycystin-1 induces resistanc ...... 3-kinase/Akt signaling pathway
@en
P2093
Alessandra Boletta
Anil K Bhunia
Gianfranco Distefano
Manila Boca
P2860
P304
P356
10.1681/ASN.2005050534
P577
2006-02-01T00:00:00Z