Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

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http://www.wikidata.org/entity/Q34654741
Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancerStrandAdvantage test for early-line and advanced-stage treatment decisions in solid tumors.Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction.5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membraneInteraction between APC and Fen1 during breast carcinogenesis.Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients.Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways.NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapyTherapeutic strategies against cancer stem cells in human colorectal cancer.Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis.Individualized predictive signatures for 5-fluorouracil-based chemotherapy in right- and left-sided colon cancer.
P2860

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy

Item
http://www.wikidata.org/entity/Q34654741
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@ast
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@en
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@nl
type
label
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@ast
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@en
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@nl
prefLabel
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@ast
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@en
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Targeting the DNA replication ...... to 5-fluorouracil chemotherapy
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932