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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane Fusion Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies Structural and molecular basis for Ebola virus neutralization by protective human antibodies Cell-targeting antibodies in immunity to Ebola Both Epistasis and Diversifying Selection Drive the Structural Evolution of the Ebola Virus Glycoprotein Mucin-Like Domain Monoclonal antibodies for the treatment of Ebola virus disease.Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials.Anti-Ebola therapies based on monoclonal antibodies: current state and challenges ahead.Mapping of Ebolavirus Neutralization by Monoclonal Antibodies in the ZMapp Cocktail Using Cryo-Electron Tomography and Studies of Cellular Entry Discovery of an antibody for pan-ebolavirus therapy The 2014 Ebola virus outbreak in West Africa highlights no evidence of rapid evolution or adaptation to humans THE STRENGTHS, WEAKNESSES, OPPORTUNITIES, AND THREATS (SWOTs) ANALYSES OF THE EBOLA VIRUS - PAPER RETRACTED.Structure of the Ebola virus glycoprotein spike within the virion envelope at 11 Å resolution.Treatment of ebola virus disease.A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses Structural basis for Marburg virus neutralization by a cross-reactive human antibody.Mechanism of human antibody-mediated neutralization of Marburg virus Chemical and Structural Aspects of Ebola Virus Entry Inhibitors.Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs Antibody Derived Peptides for Detection of Ebola Virus Glycoprotein.A thermostable, chromatographically purified Ebola nano-VLP vaccine.Human antibody repertoire after VSV-Ebola vaccination identifies novel targets and virus-neutralizing IgM antibodies.Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies.Fighting Ebola: A Window for Vaccine Re-evaluation?Ebola Virus Infection: Overview and Update on Prevention and Treatment.Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses.Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein.Quantitative serology assays for determination of antibody responses to Ebola virus glycoprotein and matrix protein in nonhuman primates and humans.Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses.Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection.Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway.Development of a Cost-effective Ovine Polyclonal Antibody-Based Product, EBOTAb, to Treat Ebola Virus Infection.Potent neutralizing monoclonal antibodies against Ebola virus infection Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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PNAS.1414164111

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Proceedings of the National Academy of Sciences of the United States of America

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Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

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Andrew B Ward

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Charles D Murin

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Larry Zeitlin

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P2860

Phylogenetic Analysis of Guinea 2014 EBOV Ebolavirus Outbreak

Vesicular stomatitis virus-based ebola vaccine is well-tolerated and protects immunocompromised nonhuman primates

Effective post-exposure treatment of Ebola infection

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

Emergence of Zaire Ebola Virus Disease in Guinea

Structural basis for differential neutralization of ebolaviruses

Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus

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Erica Ollmann Saphire

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Gary P. Kobinger

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