LEDGF, a survival factor, activates stress-related genes.
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The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tetheringHepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding proteinLens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular responseHeparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney.Virological and cellular roles of the transcriptional coactivator LEDGF/p75Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityLEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationA tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivoImpact of Chromatin on HIV ReplicationHIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cellsIdentification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integraseIntegration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner earSolution structure of the PWWP domain of the hepatoma-derived growth factor familyCharacterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression.Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy.LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoterLysophosphatidic acid enhances vascular endothelial growth factor-C expression in human prostate cancer PC-3 cells.Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy.Allosteric inhibitor development targeting HIV-1 integrase.TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replicationDisruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformationsRetroviral integration site selection.Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.Tumor-associated antigen arrays for the serological diagnosis of cancer.Confirmation of anti-DFS70 antibodies is needed in routine clinical samples with DFS staining pattern.Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG islandMenin critically links MLL proteins with LEDGF on cancer-associated target genesTranscriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75.Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism.In search of small molecules blocking interactions between HIV proteins and intracellular cofactors.Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75.Gonadotropin-regulated lymphangiogenesis in ovarian cancer is mediated by LEDGF-induced expression of VEGF-C.Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).DFS70/LEDGFp75: An Enigmatic Autoantigen at the Interface between Autoimmunity, AIDS, and Cancer.In-depth proteomic analysis of mouse cochlear sensory epithelium by mass spectrometry.The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding.PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes.
P2860
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P2860
LEDGF, a survival factor, activates stress-related genes.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
LEDGF, a survival factor, activates stress-related genes.
@ast
LEDGF, a survival factor, activates stress-related genes.
@en
LEDGF, a survival factor, activates stress-related genes.
@nl
type
label
LEDGF, a survival factor, activates stress-related genes.
@ast
LEDGF, a survival factor, activates stress-related genes.
@en
LEDGF, a survival factor, activates stress-related genes.
@nl
prefLabel
LEDGF, a survival factor, activates stress-related genes.
@ast
LEDGF, a survival factor, activates stress-related genes.
@en
LEDGF, a survival factor, activates stress-related genes.
@nl
P1476
LEDGF, a survival factor, activates stress-related genes
@en
P2093
Dhirendra P Singh
Nigar Fatma
P304
P356
10.1016/S1350-9462(02)00007-1
P577
2002-05-01T00:00:00Z