The emerging link between O-GlcNAc and Alzheimer disease. - Wikidata - wikimedia - TriplyDB

The emerging link between O-GlcNAc and Alzheimer disease.

The emerging link between O-GlcNAc and Alzheimer disease.

http://www.wikidata.org/entity/Q34683108

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The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases A critical perspective of the diverse roles of O-GlcNAc transferase in chromatin Current strategies and findings in clinically relevant post-translational modification-specific proteomics O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice Disruption of Golgi morphology and altered protein glycosylation in PLA2G6-associated neurodegeneration Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins O-GlcNAcylation Antagonizes Phosphorylation of CDH1 (CDC20 Homologue 1)O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter.Glycosylation and other PTMs alterations in neurodegenerative diseases: Current status and future role in neurotrauma.Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery.The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels.Oxidative stress induces transient O-GlcNAc elevation and tau dephosphorylation in SH-SY5Y cells.O-GlcNAcylation of the human epidermal growth factor receptor.Signaling pathways and posttranslational modifications of tau in Alzheimer's disease: the humanization of yeast cells.Protein O-GlcNAcylation: emerging mechanisms and functions.Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition.O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.Predicting the Retention Behavior of Specific O-Linked Glycopeptides.Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies Interplay between protein glycosylation pathways in Alzheimer's disease.Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development.Minireview series on the thirtieth anniversary of research on O-GlcNAcylation of nuclear and cytoplasmic proteins: Nutrient regulation of cellular metabolism and physiology by O-GlcNAcylation.O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding.Profiling of Protein O-GlcNAcylation in Murine CD8+ Effector- and Memory-like T Cells.O-GlcNAcylation is required for B cell homeostasis and antibody responses.Analytical applications of lectins.A Sweet Embrace: Control of Protein-Protein Interactions by O-Linked β-N-Acetylglucosamine.Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration.A Chemoenzymatic Histology Method for O-GlcNAc Detection.Recent advances in phosphoproteomics and application to neurological diseases.mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia.Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells.Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.

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P2860

The emerging link between O-GlcNAc and Alzheimer disease.

http://www.wikidata.org/entity/Q34683108

description

2014 nî lūn-bûn

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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

The emerging link between O-GlcNAc and Alzheimer disease.

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The emerging link between O-GlcNAc and Alzheimer disease.

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The emerging link between O-GlcNAc and Alzheimer disease.

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type

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The emerging link between O-GlcNAc and Alzheimer disease.

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The emerging link between O-GlcNAc and Alzheimer disease.

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The emerging link between O-GlcNAc and Alzheimer disease.

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prefLabel

The emerging link between O-GlcNAc and Alzheimer disease.

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The emerging link between O-GlcNAc and Alzheimer disease.

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The emerging link between O-GlcNAc and Alzheimer disease.

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JBC.R114.601351

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Journal of Biological Chemistry

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The emerging link between O-GlcNAc and Alzheimer disease

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Scott A Yuzwa

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Xiaoyang Shan

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Yanping Zhu

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase.

Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules

Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

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50

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David J Vocadlo

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267732945

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25336656

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Alzheimer's disease

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4263855

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