Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.
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The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic targetKATs in cancer: functions and therapiesHistone deacetylase inhibitors and epigenetic modifications as a novel strategy in renal cell carcinomaLysine acetyltransfer supports platelet function.The Role of Histone Acetyltransferases in Normal and Malignant HematopoiesisGrainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial-mesenchymal transition.Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration.Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer.Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress.Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis.KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9.TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition.Bromodomains and their pharmacological inhibitors.Chemical Biology for Investigating Epigenetic Functions of Lysine Acetyltransferases (KATs).Histone acetyltransferase inhibitors: where art thou?Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.A chemical probe toolbox for dissecting the cancer epigenome.Roles of Grainyhead-like transcription factors in cancer.Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers.H3K4 acetylation, H3K9 acetylation and H3K27 methylation in breast tumor molecular subtypes.A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis.
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P2860
Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.
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2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2013 թվականի ապրիլին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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Small-molecule inhibitors of a ...... are potent anticancer agents.
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Small-molecule inhibitors of a ...... are potent anticancer agents.
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Small-molecule inhibitors of a ...... are potent anticancer agents.
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Small-molecule inhibitors of a ...... are potent anticancer agents.
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Small-molecule inhibitors of a ...... are potent anticancer agents.
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Small-molecule inhibitors of a ...... g are potent anticancer agents
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Brian K Law
Christie E Pinello
Daiqing Liao
Haiching Ma
Jamie Planck
Kyla R Geary
Lisa Y Zhao
P2860
P304
P356
10.1158/1535-7163.MCT-12-0930
P50
P577
2013-04-26T00:00:00Z