Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
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Skeletal Muscle Laminopathies: A Review of Clinical and Molecular FeaturesThe nuclear envelope: an intriguing focal point for neurogenetic diseaseCardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- miceGenetic Variations Leading to Familial Dilated CardiomyopathyRecent advances in animal and human pluripotent stem cell modeling of cardiac laminopathyNovel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells.Mechanisms involving Ang II and MAPK/ERK1/2 signaling pathways underlie cardiac and renal alterations during chronic undernutritionInner nuclear membrane proteins: impact on human disease.Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation.Role of TGF-β signaling in inherited and acquired myopathies.LMNA cardiomyopathy: cell biology and genetics meet clinical medicine.Mitogen-activated protein kinase inhibitor regulation of heart function and fibrosis in cardiomyopathy caused by lamin A/C gene mutation.Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression.The cellular mastermind(?)-mechanotransduction and the nucleus.Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation.Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutationLamins in development, tissue maintenance and stress.Cardiac lipotoxicity: molecular pathways and therapeutic implications.Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene MutationsTemporal relationship of conduction system disease and ventricular dysfunction in LMNA cardiomyopathy.Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutationInhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation.Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy.ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C geneDepletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation.Novel insights into the disease etiology of laminopathies.Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways.Genetic and clinical characteristics of skeletal and cardiac muscle in patients with lamin A/C gene mutations.Key role of ERK1/2 molecular scaffolds in heart pathology.JNK inhibitors as anti-inflammatory and neuroprotective agents.Advances in basic and clinical research in laminopathies.Role of nuclear Lamin A/C in cardiomyocyte functions.What Should the Cardiologist know about Lamin Disease?How cardiomyocytes sense pathophysiological stresses for cardiac remodeling.Mechanism of interleukin-1β-induced proliferation in rat hepatic stellate cells from different levels of signal transduction.Current insights into LMNA cardiomyopathies: Existing models and missing LINCsLamin A/C Cardiomyopathies: Current Understanding and Novel Treatment Strategies.Recent Advances in Understanding and Managing Cardiomyopathy.Extracellular vesicles do not contribute to higher circulating levels of soluble LRP1 in idiopathic dilated cardiomyopathy.
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P2860
Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@ast
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@en
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@nl
type
label
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@ast
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@en
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@nl
prefLabel
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@ast
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@en
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@nl
P2093
P2860
P1433
P1476
Mitogen-activated protein kina ...... by mutation in lamin A/C gene.
@en
P2093
Antoine Muchir
Gisèle Bonne
Howard J Worman
P2860
P356
10.1161/CIRCULATIONAHA.110.970673
P407
P577
2010-12-20T00:00:00Z