Anthrax lethal and edema toxins produce different patterns of cardiovascular and renal dysfunction and synergistically decrease survival in canines
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Anthrax infectionDoes Bacillus anthracis Lethal Toxin Directly Depress Myocardial Function? A Review of Clinical Cases and Preclinical StudiesCellular and physiological effects of anthrax exotoxin and its relevance to disease.The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shockAn overview of anthrax infection including the recently identified form of disease in injection drug usersThe effects of anthrax lethal toxin on host barrier functionAnthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling networkCardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy.Pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor.Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.Molecular determinants for a cardiovascular collapse in anthraxB. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin componentsHemodynamic effects of anthrax toxins in the rabbit model and the cardiac pathology induced by lethal toxin.Structure-based redesign of an edema toxin inhibitor.Protective antigen antibody augments hemodynamic support in anthrax lethal toxin shock in canines.Bacillus anthracis edema but not lethal toxin challenge in rats is associated with depressed myocardial function in hearts isolated and tested in a Langendorff system.Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines.Acquired coagulant factor VIII deficiency induced by Bacillus anthracis lethal toxin in mice.Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring modelThe sepsis model: an emerging hypothesis for the lethality of inhalation anthraxSmall-molecule inhibitors of lethal factor protease activity protect against anthrax infection.New insights into the biological effects of anthrax toxins: linking cellular to organismal responsesToll-like receptor 4 knockout protects against anthrax lethal toxin-induced cardiac contractile dysfunction: role of autophagy.Bacillus anthracis Edema Toxin Increases Fractional Free Water and Sodium Reabsorption in an Isolated Perfused Rat Kidney Model.Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat.Centers for disease control and prevention expert panel meetings on prevention and treatment of anthrax in adults.Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support.The Potential Pathogenic Contributions of Endothelial Barrier and Arterial Contractile Dysfunction to Shock Due to B. anthracis Lethal and Edema Toxins.Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.
P2860
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P2860
Anthrax lethal and edema toxins produce different patterns of cardiovascular and renal dysfunction and synergistically decrease survival in canines
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2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Anthrax lethal and edema toxin ...... y decrease survival in canines
@ast
Anthrax lethal and edema toxin ...... y decrease survival in canines
@en
Anthrax lethal and edema toxin ...... y decrease survival in canines
@nl
type
label
Anthrax lethal and edema toxin ...... y decrease survival in canines
@ast
Anthrax lethal and edema toxin ...... y decrease survival in canines
@en
Anthrax lethal and edema toxin ...... y decrease survival in canines
@nl
prefLabel
Anthrax lethal and edema toxin ...... y decrease survival in canines
@ast
Anthrax lethal and edema toxin ...... y decrease survival in canines
@en
Anthrax lethal and edema toxin ...... y decrease survival in canines
@nl
P2093
P2860
P356
P1476
Anthrax lethal and edema toxin ...... y decrease survival in canines
@en
P2093
Charles Natanson
Daniel A Sweeney
Dara Scher
David A Vitberg
G Mani Subramanian
Peter Q Eichacker
Robert L Danner
Steven B Solomon
Thi S Migone
Xizhong Cui
P2860
P304
P356
10.1086/657408
P407
P577
2010-11-10T00:00:00Z