Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial - Wikidata - wikimedia - TriplyDB

Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial

Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial

http://www.wikidata.org/entity/Q34720308

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Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents Glycotherapy: new advances inspire a reemergence of glycans in medicine Breast cancer vaccines: a clinical reality or fairy tale?Development, characterization, and immunotherapeutic use of peptide mimics of the Thomsen-Friedenreich carbohydrate antigen.Protein modifications as potential biomarkers in breast cancer.Metabolic engineering of Agrobacterium sp. strain ATCC 31749 for production of an alpha-Gal epitope.Design and synthesis of potent Quillaja saponin vaccine adjuvants Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4.On the power of chemical synthesis: immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines.Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen.The glycosphingolipid P₁ is an ovarian cancer-associated carbohydrate antigen involved in migration.A practical total synthesis of globo-H for use in anticancer vaccines.Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer Human monoclonal antibodies to sialyl-Lewis (CA19.9) with potent CDC, ADCC, and antitumor activity The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research.The case for polyvalent cancer vaccines that induce antibodies.Inhibition of spontaneous breast cancer metastasis by anti-Thomsen-Friedenreich antigen monoclonal antibody JAA-F11 Cancer vaccines and carbohydrate epitopes.Recent Development in Carbohydrate Based Anti-cancer Vaccines.Infusion of Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate-Conjugated MOG35-55-Coupled Spleen Cells Effectively Prevents and Reverses Experimental Autoimmune Encephalomyelitis in Mice A facile method for oxidation of primary alcohols to carboxylic acids and its application in glycosaminoglycan syntheses.Triterpenoid saponins from the roots of Acanthophyllum gypsophiloides Regel.Novel therapeutic approaches for small cell lung cancer: the future has arrived Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans.Carbohydrate vaccines as immunotherapy for cancer.Antibody repertoire profiling with mimotope arrays.Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities.Towards a therapeutic breast cancer vaccine: the next steps.Posttranslational protein modifications: current implications for cancer detection, prevention, and therapeutics.A Fully Synthetic Self-Adjuvanting Globo H-Based Vaccine Elicited Strong T Cell-Mediated Antitumor Immunity.Breast cancer immunobiology driving immunotherapy: vaccines and immune checkpoint blockade.A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission Clustered carbohydrates in synthetic vaccines.Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer.Multi-component one-pot synthesis of the tumor-associated carbohydrate antigen Globo-H based on preactivation of thioglycosyl donors.Vaccine immunotherapy in breast cancer treatment: promising, but still early.Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis.Glycan antagonists and inhibitors: a fount for drug discovery.Immunization with N-propionyl polysialic acid-KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci.

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P2860

Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial

http://www.wikidata.org/entity/Q34720308

description

2001 nî lūn-bûn

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2001 թուականի Մարտին հրատարակուած գիտական յօդուած

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2001 թվականի մարտին հրատարակված գիտական հոդված

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Immunization of metastatic bre ...... o H conjugate: a phase I trial

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P2093

A N Houghton

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C A Hudis

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C Musselli

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K P Bencsath

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K S Panageas

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M Spassova

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P O Livingston

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P2860

Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain

Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens.

Carbohydrate vaccines in cancer: immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man.

Development of a new vaccine formulation that enhances the immunogenicity of tumor-associated antigen CaMBr1.

Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21.

Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease.

Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma.

Carbohydrate vaccines that induce antibodies against cancer. 2. Previous experience and future plans.

Carbohydrate vaccines that induce antibodies against cancer. 1. Rationale.

Antibodies against autologous tumor cell proteins in patients with small-cell lung cancer: association with improved survival.

P304

3270-3275

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10.1073/PNAS.051626298

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6

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12084447

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11248068

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phase I clinical trial

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30643

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