Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
about
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Role of Nrf2 in oxidative stress and toxicityUbiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathwayThe GI-GPx gene is a target for Nrf2Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive elementExtremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stressKeap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stressNrf2 is a direct PERK substrate and effector of PERK-dependent cell survivalAdvances in mechanisms of anti-oxidationPharmacology and Clinical Drug Candidates in Redox MedicineModulation of oxidative stress and mitochondrial function by the ketogenic dietEffect of redox modulating NRF2 activators on chronic kidney diseaseEmerging roles of Nrf2 signal in non-small cell lung cancerTrxR1 as a potent regulator of the Nrf2-Keap1 response systemAntioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductaseThe Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasmDirect evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersA generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signalingSmall molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsRegulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disordersAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemBasic principles and emerging concepts in the redox control of transcription factorsChemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoidsAntioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistanceLocalization of oleuropeyl glucose esters and a flavanone to secretory cavities of MyrtaceaeNrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genesOral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringensCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsOxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducersDistinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stressA chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells.Protein damage by reactive electrophiles: targets and consequencesNrf2: friend or foe for chemoprevention?Effect of antioxidant-enriched diets on glutathione redox status in tissue homogenates and mitochondria of the senescence-accelerated mouseTranscription factors in the cellular signaling network as prime targets of chemopreventive phytochemicalsInteractions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention
P2860
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P2860
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@ast
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@en
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@nl
type
label
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@ast
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@en
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@nl
prefLabel
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@ast
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@en
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@nl
P2093
P2860
P356
P1476
Potency of Michael reaction ac ...... ctivity with sulfhydryl groups
@en
P2093
P2860
P304
P356
10.1073/PNAS.051632198
P407
P577
2001-03-01T00:00:00Z