The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm
about
Recent advances in understanding myelofibrosis and essential thrombocythemiaInflammation as a Driver of Clonal Evolution in Myeloproliferative NeoplasmThe secret life of a megakaryocyte: emerging roles in bone marrow homeostasis controlThrombopoietin and its receptor in normal and neoplastic hematopoiesis.The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.Increased B cell activation is present in JAK2V617F-mutated, CALR-mutated and triple-negative essential thrombocythemia.A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells.JAK2V617F-mutant megakaryocytes contribute to hematopoietic stem/progenitor cell expansion in a model of murine myeloproliferation.Oncogenic Drivers in Myeloproliferative Neoplasms: From JAK2 to Calreticulin Mutations.Overview of Transgenic Mouse Models of Myeloproliferative Neoplasms (MPNs).Myeloproliferative neoplasm stem cells.JAK2V617F-mutant vascular niche contributes to JAK2V617F clonal expansion in myeloproliferative neoplasms.Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling.The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms.Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.JAK2V617F-bearing vascular niche enhances malignant hematopoietic regeneration following radiation injury.
P2860
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P2860
The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm
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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@ast
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@en
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@nl
type
label
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@ast
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@en
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@nl
prefLabel
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@ast
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@en
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@nl
P2093
P2860
P1433
P1476
The thrombopoietin receptor, M ...... ed myeloproliferative neoplasm
@en
P2093
Kenneth Kaushansky
S Leah Etheridge
Veena Sangkhae
P2860
P304
P356
10.1182/BLOOD-2014-07-587238
P407
P577
2014-10-22T00:00:00Z