Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. - Wikidata - wikimedia - TriplyDB

Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.

Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.

http://www.wikidata.org/entity/Q34743616

about

Prolyl isomerase Pin1 in cancer Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer.Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer Kinetic analysis of BCL11B multisite phosphorylation-dephosphorylation and coupled sumoylation in primary thymocytes by multiple reaction monitoring mass spectroscopy.Prolyl isomerases in gene transcription Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α.Roles of Prolyl Isomerases in RNA-Mediated Gene Expression Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells.Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation.Differential regulation of cellular senescence and differentiation by prolyl isomerase Pin1 in cardiac progenitor cells Regulation of transcription factor activity by interconnected post-translational modifications.Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.MYC degradation Deubiquitinating c-Myc: USP36 steps up in the nucleolus.Inhibition of CDK-mediated Smad3 phosphorylation reduces the Pin1-Smad3 interaction and aggressiveness of triple negative breast cancer cells.The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target.SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62.PIN1 in breast development and cancer: a clinical perspective.MYC Modulation around the CDK2/p27/SKP2 Axis [How does the apicomplexan parasite Theileria control host cell identity?].Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.The impact of phosphatases on proliferative and survival signaling in cancer.Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals Identification of a novel c-Myc inhibitor with antitumor effects on multiple myeloma cells Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells Gears-In-Motion: The Interplay of WW and PPIase Domains in Pin1

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Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.

http://www.wikidata.org/entity/Q34743616

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2013年の論文

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Molecular and Cellular Biology

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Pin1 regulates the dynamics of ...... ne regulation and oncogenesis.

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Amy S Farrell

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Carl Pelz

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Charlie Morgan

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Colin J Daniel

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Mahnaz Janghorban

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Rosalie C Sears

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Soren Impey

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Xiaoli Zhang

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Xiaoyan Wang

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Yulong Su

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P2860

Intrinsically unstructured proteins and their functions

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc

Proteomic profiling of Myc-associated proteins

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

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2930-2949

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10.1128/MCB.01455-12

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15

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33

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2013-05-28T00:00:00Z

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23716601

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3719674

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