Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
about
Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic strokeImpaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1Cytoprotective-selective activated protein C therapy for ischaemic strokeCerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's diseaseNeurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitroRoles of protease-activated receptors in a mouse model of endotoxemia.Roles of inflammation and the activated protein C pathway in the brain edema associated with cerebral venous sinus thrombosis.Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impactNeurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease.Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impactEngineering thrombin for selective specificity toward protein C and PAR1.Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrierEvidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.WEDGE: an anticoagulant thrombin mutant produced by autoactivation.Activated protein C: biased for translation.Anticoagulant drugs: an update.Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases.Levels of plasma des-gamma-carboxy protein C and prothrombin in patients with liver diseasesThe anticoagulant protein C pathway.Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic strokeCytoprotective protein C pathways and implications for stroke and neurological disordersNeuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons.Thrombin.New therapeutic targets in the neurovascular pathway in Alzheimer's disease.Activated protein C promotes neuroprotection: mechanisms and translation to the clinic.Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity.Neuroprotective activities of activated protein C mutant with reduced anticoagulant activityThe role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease.AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis.Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1.Barrier enhancing signals in pulmonary edema.Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor.Activated protein C mediates a healing phenotype in cultured tenocytes.Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C.Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing.Thrombomodulin-independent activation of protein C and specificity of hemostatically active snake venom serine proteinases: crystal structures of native and inhibited Agkistrodon contortrix contortrix protein C activator.Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions.PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke.
P2860
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P2860
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@ast
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@en
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@nl
type
label
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@ast
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@en
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@nl
prefLabel
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@ast
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@en
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@nl
P2093
P356
P1476
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.
@en
P2093
Berislav Zlokovic
John H Griffin
José A Fernández
P304
P356
10.1053/SHEM.2002.34093
P577
2002-07-01T00:00:00Z