Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. - Wikidata - wikimedia - TriplyDB

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

http://www.wikidata.org/entity/Q34750222

about

A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue New insights from monogenic diabetes for "common" type 2 diabetes Early life factors and type 2 diabetes mellitus Genetic, epigenetic, and environmental contributions to neural tube closure Genetic and epigenetic control of metabolic health Nutritional Influence on Epigenetic Marks and Effect on Livestock Production Gender Differences in Adipocyte Metabolism and Liver Cancer Progression Natural history of β-cell adaptation and failure in type 2 diabetes Epigenetic Regulation of Islet Development and Regeneration Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice DNA methylation patterns in cord blood DNA and body size in childhood Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes Early developmental conditioning of later health and disease: physiology or pathophysiology?Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes.Inactive or moderately active human promoters are enriched for inter-individual epialleles.Intrauterine Growth Retardation - A Developmental Model of Type 2 Diabetes.Association between Obesity and Parental Weight Status in Children and Adolescents Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming.Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis Genome-wide meta-analysis of genetic susceptible genes for Type 2 Diabetes.DNA methylation signatures link prenatal famine exposure to growth and metabolism Identification of the control region of pancreatic expression of Bmp4 in vitro and in vivo.Young capillary vessels rejuvenate aged pancreatic islets Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.A systems view of epigenetic networks regulating pancreas development and β-cell function Effect of vitamin B deprivation during pregnancy and lactation on homocysteine metabolism and related metabolites in brain and plasma of mice offspring Maternal diet, aging and diabetes meet at a chromatin loop.Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?Environment-sensitive epigenetics and the heritability of complex diseases.Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring

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P2860

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

http://www.wikidata.org/entity/Q34750222

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2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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Maternal diet and aging alter ...... gene in rat pancreatic islets

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Laura P O'Neill

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Marloes Dekker Nitert

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Matthew Ackers-Johnson

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Mohammed Tadayyon

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Noel H Smith

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R Huw Jones

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Santiago Uribe-Lewis

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Victor E Marquez

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William Cairns

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Yoko Ito

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P2860

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Control of pancreas and liver gene expression by HNF transcription factors

The complex language of chromatin regulation during transcription

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.

An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types

Environmental epigenomics and disease susceptibility

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

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5449-5454

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13

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108

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Miguel Constancia

Ionel Sandovici

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2011-03-08T00:00:00Z

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235617267

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21385945

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3069181

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