An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients. - Wikidata - wikimedia - TriplyDB

An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients.

An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients.

http://www.wikidata.org/entity/Q34754308

about

Antidepressant drugs for narcolepsy Control of sleep and wakefulness Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models Treatment paradigms for cataplexy in narcolepsy: past, present, and future International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors Unmet needs of patients with narcolepsy: perspectives on emerging treatment options Narcolepsy: neural mechanisms of sleepiness and cataplexy Pharmacotherapy options for cataplexy Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep.Update on the treatment of narcolepsy: clinical efficacy of pitolisant The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers Histamine in the regulation of wakefulness.Histaminergic system in brain disorders: lessons from the translational approach and future perspectives.The histamine H3 receptor: from discovery to clinical trials with pitolisant LC-MS/MS method for the determination of pitolisant: application to rat pharmacokinetic and brain penetration studies.Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey.Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency.Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions Animal models of narcolepsy.Enhanced histaminergic neurotransmission and sleep-wake alterations, a study in histamine H3-receptor knock-out mice.Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers.Impact of Astroglial Connexins on Modafinil Pharmacological Properties.Preclinical evaluation of the abuse potential of Pitolisant, a histamine H₃ receptor inverse agonist/antagonist compared with Modafinil Behavioral responses of dopamine beta-hydroxylase knockout mice to modafinil suggest a dual noradrenergic-dopaminergic mechanism of action.CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome.Enhancing attention in neurodegenerative diseases: current therapies and future directions.Histamine H3 and H4 receptors as novel drug targets.Expert opinion on pharmacotherapy of narcolepsy.Nonmotor disturbances in Parkinson's disease.The waking brain: an update.Sleep neurobiology from a clinical perspective.Waking with the hypothalamus.Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?Histamine pharmacology and new CNS drug targets.The histaminergic network in the brain: basic organization and role in disease.Current and emerging options for the drug treatment of narcolepsy.Orquestic regulation of neurotransmitters on reward-seeking behavior.Pharmacological management of narcolepsy and cataplexy in pediatric patients.Interactions of the orexin/hypocretin neurones and the histaminergic system.

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P2860

An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients.

http://www.wikidata.org/entity/Q34754308

description

2007 nî lūn-bûn

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2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

An inverse agonist of the histamine H

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An inverse agonist of the hist ...... n orexin-/- mice and patients.

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An inverse agonist of the hist ...... n orexin-/- mice and patients.

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An inverse agonist of the histamine H

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An inverse agonist of the hist ...... n orexin-/- mice and patients.

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An inverse agonist of the hist ...... n orexin-/- mice and patients.

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An inverse agonist of the histamine H

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An inverse agonist of the hist ...... n orexin-/- mice and patients.

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An inverse agonist of the hist ...... n orexin-/- mice and patients.

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J.NBD.2007.12.003

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Neurobiology of Disease

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An inverse agonist of the hist ...... n orexin-/- mice and patients.

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David Perrin

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Hélène Bastuji

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Jean-Charles Schwartz

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Jeanne-Marie Lecomte

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10.1016/J.NBD.2007.12.003

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30

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Isabelle Arnulf

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Jean-Charles Schwartz

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