A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
about
Molecular candidates for cardiac stretch-activated ion channelsTemperature sensitivity of two-pore (K2P) potassium channelsCardiac Mechano-Gated Ion Channels and Arrhythmias.Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold librariesTransmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.Pathophysiological significance of the two-pore domain K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset from a chemically-induced murine inflammatory bowel disease model.Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties.Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels.Regulating excitability of peripheral afferents: emerging ion channel targets.TREK-king the blood-brain-barrier.Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.The family of K2P channels: salient structural and functional properties.Potassium and Sodium Transport in Yeast.K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.Breaking barriers to novel analgesic drug development.Discovery of anthranilamides as a novel class of inhibitors of neurotropic alphavirus replication.A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles.Ion channels find a pathway for therapeutic success.Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance.GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox
P2860
Q27003167-B973BCC6-9129-4276-A41A-4E5CF35E5A65Q27021286-A363D2F6-CA8E-417E-A105-1E0FE1519916Q28601309-14BD802B-26E8-4EFA-B383-EDC1917C59ECQ34249746-6C5B7060-7CF9-4D2A-BD06-C172D2B493A3Q34734923-CA3B17EF-0D09-42B1-8648-BE8886993095Q36180152-D6E47F35-28D8-4787-B629-2D52F9D9395FQ36209231-1E567A0A-38BD-40CB-BD59-3EEDA2AF446EQ36821471-6071A55C-CDCE-4D53-AE12-71CF33E7A0ECQ36830145-4137EE8A-DF7B-4E56-9D2C-AEFAA9C9777CQ36931176-CD9D2785-A439-49B4-82E4-F6160D12C1F2Q38182826-20AB7D0B-D1ED-4D56-9E34-AC352CC851CBQ38190042-8C51D22F-C02F-425F-BE7E-E98C6EFEF569Q38270913-CE720C83-9B30-4EF5-8586-2D9868D0DC38Q38296300-0334C5E9-8B50-4F22-9F63-8F44046962C9Q38684267-0700C161-FF92-4830-9161-78B4B200BB58Q38686094-F1CA3BA1-D507-4C3B-85F6-5EED0AFD1121Q39360773-0721CF02-3094-4CE3-BD74-CF93303707D9Q41449946-E1E4CEF6-868A-4895-AFEA-4F77EC271403Q42027548-85D48701-0458-4A12-B69C-792A7C2BB93AQ42765527-DE182729-A11F-48D6-AF58-6A4B078A4B42Q47748973-FCE87D1C-5377-4F3E-AAFC-5E31604A61D1Q48278693-D2912EFD-6BBD-480D-BC8B-49B536535108Q55439672-FBA7102D-4C73-4AE2-9423-BDA104E02E6BQ57178143-5CD5E985-03D1-45B0-918C-B94238840180
P2860
A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
A high-throughput functional s ...... echano-sensitive K2P channels.
@ast
A high-throughput functional s ...... echano-sensitive K2P channels.
@en
A high-throughput functional s ...... echano-sensitive K2P channels.
@nl
type
label
A high-throughput functional s ...... echano-sensitive K2P channels.
@ast
A high-throughput functional s ...... echano-sensitive K2P channels.
@en
A high-throughput functional s ...... echano-sensitive K2P channels.
@nl
prefLabel
A high-throughput functional s ...... echano-sensitive K2P channels.
@ast
A high-throughput functional s ...... echano-sensitive K2P channels.
@en
A high-throughput functional s ...... echano-sensitive K2P channels.
@nl
P2093
P2860
P356
P1433
P1476
A high-throughput functional s ...... echano-sensitive K2P channels.
@en
P2093
Alejandra Gallardo-Godoy
Daniel L Minor
Kean-Hooi Ang
Kimberly A Clark
Michelle R Arkin
Sviatoslav N Bagriantsev
P2860
P304
P356
10.1021/CB400289X
P577
2013-06-17T00:00:00Z