Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. - Wikidata - wikimedia - TriplyDB

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.

http://www.wikidata.org/entity/Q34768688

about

Oligonucleotide therapeutic approaches for Huntington disease Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic Considerations Subverting Subversion: A Review on the Breast Cancer Microenvironment and Therapeutic Opportunities Progress and Prospects of Anti-HBV Gene Therapy Development Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases Neuronal dark matter: the emerging role of microRNAs in neurodegeneration Adeno-associated virus-mediated microRNA delivery and therapeutics Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice Targeting mRNA for the treatment of facioscapulohumeral muscular dystrophy Challenges and Prospects for Alpha-1 Antitrypsin Deficiency Gene Therapy Current prospects for RNA interference-based therapies Construction of permanently inducible miRNA-based expression vectors using site-specific recombinases Epigenetic mechanisms of neurodegeneration in Huntington's disease Targeted delivery of mutant tolerant anti-coxsackievirus artificial microRNAs using folate conjugated bacteriophage Phi29 pRNA Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons Targeting several CAG expansion diseases by a single antisense oligonucleotide Expression of multiple artificial microRNAs from a chicken miRNA126-based lentiviral vector Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs RNA Interference and Cancer Therapy Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing.Improved knockdown from artificial microRNAs in an enhanced miR-155 backbone: a designer's guide to potent multi-target RNAi Organic small hairpin RNAs (OshR): a do-it-yourself platform for transgene-based gene silencing.Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease.Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo Effective heritable gene knockdown in zebrafish using synthetic microRNAs.Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats.An artificial miRNA against HPSE suppresses melanoma invasion properties, correlating with a down-regulation of chemokines and MAPK phosphorylation.A construct with fluorescent indicators for conditional expression of miRNA.Heritable and lineage-specific gene knockdown in zebrafish embryo Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype.Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system

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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.

http://www.wikidata.org/entity/Q34768688

description

2008 nî lūn-bûn

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2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի ապրիլին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

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Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

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Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

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type

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Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

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Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

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Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

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prefLabel

Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

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Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

@en

Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

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PNAS.0801775105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Artificial miRNAs mitigate shR ...... erapeutic development of RNAi.

@en

P2093

Alex Mas Monteys

http://www.w3.org/2001/XMLSchema#string

Barrie J Carter

http://www.w3.org/2001/XMLSchema#string

Barry Polisky

http://www.w3.org/2001/XMLSchema#string

Beverly L Davidson

http://www.w3.org/2001/XMLSchema#string

Brian L Gilmore

http://www.w3.org/2001/XMLSchema#string

Haim Burstein

http://www.w3.org/2001/XMLSchema#string

Inâs Martins

http://www.w3.org/2001/XMLSchema#string

Jodi L McBride

http://www.w3.org/2001/XMLSchema#string

Patrick D Staber

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Richard W Peluso

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P2860

An extensive class of small RNAs in Caenorhabditis elegans

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

Identification of novel genes coding for small expressed RNAs

Functional siRNAs and miRNAs exhibit strand bias

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

Rational siRNA design for RNA interference

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5868-5873

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scholarly article

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10.1073/PNAS.0801775105

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15

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105

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Ryan L. Boudreau

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2008-04-08T00:00:00Z

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5454751

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18398004

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2311380

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