The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.
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c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's DiseaseMLK3 regulates fMLP-stimulated neutrophil motility.Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft modelAdjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disordersLeucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disordersDidehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic miceLong-acting slow effective release antiretroviral therapy.The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapyThe mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradationA biological perspective of CSF lipids as surrogate markers for cognitive status in HIVMicroglia and synapse: interactions in health and neurodegenerationAn Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?Neuropharmacologic Approaches to Restore the Brain's Microenvironment.Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugsInterplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications.MLK3 regulates FRA-1 and MMPs to drive invasion and transendothelial migration in triple-negative breast cancer cells.Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis.Ultrastructure of microglia-synapse interactions in the HIV-1 Tat-injected murine central nervous systemDark microglia: A new phenotype predominantly associated with pathological states.Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity.URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease.
P2860
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P2860
The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@ast
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@en
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@nl
type
label
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@ast
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@en
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@nl
prefLabel
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@ast
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@en
The new small-molecule mixed-l ...... ated neurocognitive disorders.
@nl
P2093
P2860
P50
P1476
The new small-molecule mixed-l ...... iated neurocognitive disorders
@en
P2093
Colin J Loweth
Daniel F Marker
E Chris Muly
Jenna M Puccini
Justin Barbieri
Mary A Gantz Marker
Shao-Ming Lu
Val S Goodfellow
P2860
P304
9998-10010
P356
10.1523/JNEUROSCI.0598-13.2013
P407
P577
2013-06-01T00:00:00Z