CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells.
about
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasisArginine methyltransferases as novel therapeutic targets for breast cancerDisruptive environmental chemicals and cellular mechanisms that confer resistance to cell deathPELP1 oncogenic functions involve CARM1 regulationGlobal mapping of CARM1 substrates defines enzyme specificity and substrate recognition.Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors.Chemical biology of protein arginine modifications in epigenetic regulationHistone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription.MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer Suppression.Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-positive breast tumorigenesis.Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells.Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity.Epigenetic regulation of estrogen signaling in breast cancerCARM1 automethylation is controlled at the level of alternative splicing.Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.A TR-FRET-based functional assay for screening activators of CARM1Lapatinib induces p27(Kip1)-dependent G₁ arrest through both transcriptional and post-translational mechanismsThe role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation.miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1.Protein arginine methyltransferases (PRMTs) as therapeutic targets.Role of PRMTs in cancer: Could minor isoforms be leaving a mark?Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.Inhibitors of Protein Methyltransferases and Demethylases.Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation.Conference scene: 2nd cancer epigenetics conference.Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes.Elevated CRB3 expression suppresses breast cancer stemness by inhibiting β-catenin signalling to restore tamoxifen sensitivity.CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α.Cancer-related transcription regulator protein NAC1 forms a protein complex with CARM1 for ovarian cancer progression.Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors
P2860
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P2860
CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
CARM1 is an important determin ...... ration in breast cancer cells.
@ast
CARM1 is an important determin ...... ration in breast cancer cells.
@en
CARM1 is an important determin ...... ration in breast cancer cells.
@nl
type
label
CARM1 is an important determin ...... ration in breast cancer cells.
@ast
CARM1 is an important determin ...... ration in breast cancer cells.
@en
CARM1 is an important determin ...... ration in breast cancer cells.
@nl
prefLabel
CARM1 is an important determin ...... ration in breast cancer cells.
@ast
CARM1 is an important determin ...... ration in breast cancer cells.
@en
CARM1 is an important determin ...... ration in breast cancer cells.
@nl
P2093
P2860
P1433
P1476
CARM1 is an important determin ...... ration in breast cancer cells.
@en
P2093
Georgios P Skliris
Ken Higashimato
Kevin P White
Mariam Al-Dhaheri
Paul Lambert
Yidan Wang
Yuerong Zhu
P2860
P304
P356
10.1158/0008-5472.CAN-10-2426
P407
P577
2011-01-31T00:00:00Z