Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
about
Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAASAtomic structure of the cross-β spine of islet amyloid polypeptide (amylin)Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the processProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusAmyloidogenicity and cytotoxicity of recombinant mature human islet amyloid polypeptide (rhIAPP).Aromaticity and amyloid formation: effect of π-electron distribution and aryl substituent geometry on the self-assembly of peptides derived from hIAPP(22-29).Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesisAmyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptideSedimentation studies on human amylin fail to detect low-molecular-weight oligomersEvidence of π-stacking interactions in the self-assembly of hIAPP(22-29).Electrochemical Assay of Human Islet Amyloid Polypeptide and Its AggregationEvidence for a partially structured state of the amylin monomerAtomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.Regulation of the aggregation behavior of human islet amyloid polypeptide fragment by titanocene complexes.Combination of kinetically selected inhibitors in trans leads to highly effective inhibition of amyloid formation.The role of the 14-20 domain of the islet amyloid polypeptide in amyloid formationAmylin uncovered: a review on the polypeptide responsible for type II diabetes.Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid containing α/β and α/γ Hybrid Peptidomimetics.Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptideClick Peptide concept: o-acyl isopeptide of islet amyloid polypeptide as a nonaggregative precursor molecule.Dissecting the role of single regions of an IAPP mimic and IAPP in inhibition of Aβ40 amyloid formation and cytotoxicity.Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation.Common fibrillar spines of amyloid-β and human Islet Amyloid Polypeptide revealed by Micro Electron Diffraction and inhibitors developed using structure-based design.Membrane-mediated amyloid deposition of human islet amyloid polypeptide.Islet Amyloid Polypeptide Promotes Amyloid-beta Aggregation by Binding-induced Helix-unfolding of the Amyloidogenic Core.Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes.RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity.Polymorphic cross-seeding amyloid assemblies of amyloid-β and human islet amyloid polypeptide.Nanoscale Heterogeneity of the Molecular Structure of Individual hIAPP Amyloid Fibrils Revealed with Tip-Enhanced Raman Spectroscopy.Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies
P2860
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P2860
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@ast
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@en
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@nl
type
label
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@ast
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@en
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@nl
prefLabel
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@ast
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@en
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@nl
P2860
P1433
P1476
Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.
@en
P2093
Kapurniotu A
P2860
P304
P356
10.1002/1097-0282(2001)60:6<438::AID-BIP10182>3.0.CO;2-A
P577
2001-01-01T00:00:00Z