Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist
about
Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein InteractionsDithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptidesConstraining cyclic peptides to mimic protein structure motifs.Towards vast libraries of scaffold-diverse, conformationally constrained oligomers.Utility of redundant combinatorial libraries in distinguishing high and low quality screening hitsEarly endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery.Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcMDirect Ras Inhibitors Identified from a Structurally Rigidified Bicyclic Peptide Library.Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.Direct comparison of linear and macrocyclic compound libraries as a source of protein ligandsChemical tools to monitor and manipulate the adaptive immune system.Rapid lead discovery through iterative screening of one bead one compound libraries.Methods for the creation of cyclic Peptide libraries for use in lead discovery.Targeting protein-protein interfaces using macrocyclic peptides.Antitumor and antimicrobial activity of some cyclic tetrapeptides and tripeptides derived from marine bacteria.Synthesis of a large library of macrocyclic peptides containing multiple and diverse N-alkylated residues.High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies.A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis.Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides.Iminoboronate-Based Peptide Cyclization That Responds to pH, Oxidation, and Small Molecule Modulators.In-Bead Screening of Hydroxamic Acids for the Identification of HDAC Inhibitors.Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library.Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus.Sequence-Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications.A Selective, Cell-Permeable Nonphosphorylated Bicyclic Peptidyl Inhibitor against Peptidyl-Prolyl Isomerase Pin1.An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional ScreeningBicyclic Peptides as Next-Generation Therapeutics.Targeting Stereotyped B Cell Receptors from Chronic Lymphocytic Leukemia Patients with Synthetic Antigen Surrogates.Chemical Tools To Monitor and Manipulate Adaptive Immune Responses.New Modalities for Challenging Targets in Drug Discovery.Modulating protein-protein interactions: the potential of peptides.A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cellsRational, computer-enabled peptide drug design: principles, methods, applications and future directions.Systematic Targeting of Protein-Protein InteractionsCell-permeable bicyclic peptide inhibitors against intracellular proteins.Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp3)-H activation.Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides.Facile Synthesis of a Next Generation Safety-Catch Acid-Labile Linker, SCAL-2, Suitable for Solid-Phase Synthesis, On-Support Display and for Post-Synthesis Tagging.One-Bead-Two-Compound Thioether Bridged Macrocyclic γ-AApeptide Screening Library against EphA2.Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides.
P2860
Q26777298-AD7AB670-77CB-40AD-B6D9-39DB6BE90E32Q27695729-5C6E8A81-E0EB-4C51-A79C-C2534B35C2DDQ30367509-CB61C6A8-5FC7-463F-853E-980A11CB234DQ30748083-A7B3B248-B235-4686-A354-E6C9CEB6181CQ33739175-D04A634A-2F6A-4099-A167-028EC30A2244Q33824686-75D571A4-3556-4B49-B5DB-0595A53B4525Q33951197-D0D86F9E-A88C-41F7-A79D-77D88457E533Q34271187-F7874731-C497-4C04-937E-DDF49FFE53A1Q35111060-F86056B6-B9B8-41BF-864E-07E271182D3EQ35166727-B18C9F61-D161-4806-83FB-94B44550429BQ35264291-CA5E30CD-0DAA-4C0B-BDA2-9D1CE453BE6BQ35461662-065CFDE5-8DAD-4ACD-8BDA-A939577CCC79Q35542409-D630302D-D1B9-40C4-B02F-5D44B05DA790Q35558196-B17FA99C-4DB8-4718-B0AB-D2EA05AD715AQ35657498-39651D23-2058-4A3E-9813-FDC350D18EC5Q35661360-4236056D-088A-4FC2-AE19-568D28CC671AQ35661419-BE500B0A-64A8-40C6-BAD3-E83C8D9C24C2Q35848294-1DA2E12A-360B-48D2-A67C-083E17EE8D85Q35863269-F16754C4-65DA-4837-80DD-5546BF810623Q35917996-B3E09E39-0B66-4E26-8AE3-440116E9E9DFQ35946566-8B38D9E7-8DBB-42C4-AC98-BA4A35FF8D46Q36012507-E1765257-C4D6-45A1-89B6-ED00A3F0C68BQ36019487-84603AB8-1209-4D0B-95CC-A03E865550C3Q36065500-5501632F-AAA1-4470-8308-49D811CBD5F4Q36124025-DA5B93BF-CE93-4AAD-9DA6-4C0CC6520823Q36281478-5F3C0B9C-C006-4ABF-B7E0-CA9255F6521AQ36394825-0BE3E261-8887-4DC9-85F6-3A34DACA6B92Q36755058-6D9DA11F-06DA-464A-9C70-0D107F76DD8FQ37675090-154B6ACD-4577-4769-B04C-D7FE631FC8D9Q38289100-FA6E7D55-60B6-4307-BA01-A226E8C58B7DQ38314370-7DBD1312-0C85-44FF-B98B-16620A316F1AQ38444221-A6B54FBC-2A21-47BD-AD8E-5B7664578EC2Q38618616-7FF65623-24FA-400D-8256-9B6841E78BEFQ38856802-D3A0F94A-D10F-41B9-A469-33FD737BBE5DQ38980364-A899B3F5-0794-44CE-B4FE-B3B97C93E8D2Q41528002-8BB26D1C-9109-4CAA-9CB6-072D4BF0BC73Q43055439-EBE73203-77DC-476B-9B9F-585D9018E229Q47165741-4E79A0F6-8F24-4E6C-80F3-534AE795A9D7Q47431602-A66A0B72-F578-4CE1-91C3-1820C31A1466Q48146156-472E8864-EE15-428B-B150-D0434C35A313
P2860
Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@ast
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@en
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@nl
type
label
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@ast
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@en
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@nl
prefLabel
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@ast
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@en
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@nl
P2093
P2860
P356
P1476
Screening bicyclic peptide lib ...... r necrosis factor-α antagonist
@en
P2093
Curran A Rhodes
Punit Upadhyaya
Wenlong Lian
P2860
P304
11990-11995
P356
10.1021/JA405106U
P407
P577
2013-08-01T00:00:00Z