Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models
about
Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: lack of dependence upon opioid receptor activation.Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedsideCB2: a cannabinoid receptor with an identity crisisChronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawalThe CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects.Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signallingTolerance to chronic delta-9-tetrahydrocannabinol (Δ⁹-THC) in rhesus macaques infected with simian immunodeficiency virusCB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor painCannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation2,3-Dihydro-1-benzofuran derivatives as a series of potent selective cannabinoid receptor 2 agonists: design, synthesis, and binding mode prediction through ligand-steered modeling.Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands.CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain.Latest advances in cannabinoid receptor agonists.Dynamic changes to the endocannabinoid system in models of chronic pain.Novel thiazole derivatives: a patent review (2008 - 2012. Part 2).Modulating the delicate glial-neuronal interactions in neuropathic pain: promises and potential caveats.Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands.The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.Combination Chemistry: Structure-Activity Relationships of Novel Psychoactive Cannabinoids.Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia.The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief.Evaluation of first generation synthetic cannabinoids on binding at non-cannabinoid receptors and in a battery of in vivo assays in mice.Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in ratsLegal controls on cannabimimetics: an international dilemma?Radioligands for positron emission tomography imaging of cannabinoid type 2 receptor.Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings.Highly selective CB2 receptor agonist A836339 has gastroprotective effect on experimentally induced gastric ulcers in mice.
P2860
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P2860
Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Characterization of a cannabin ...... al assays, in vivo pain models
@ast
Characterization of a cannabin ...... al assays, in vivo pain models
@en
Characterization of a cannabin ...... al assays, in vivo pain models
@nl
type
label
Characterization of a cannabin ...... al assays, in vivo pain models
@ast
Characterization of a cannabin ...... al assays, in vivo pain models
@en
Characterization of a cannabin ...... al assays, in vivo pain models
@nl
prefLabel
Characterization of a cannabin ...... al assays, in vivo pain models
@ast
Characterization of a cannabin ...... al assays, in vivo pain models
@en
Characterization of a cannabin ...... al assays, in vivo pain models
@nl
P2093
P921
P356
P1476
Characterization of a cannabin ...... al assays, in vivo pain models
@en
P2093
Anita K Salyers
Ann E Tovcimak
Anthony V Daza
Betty B Yao
Bradley A Hooker
Chang Z Zhu
Chengmin Zhong
Chih-Liang Chin
Erica J Wensink
George K Grayson
P304
P356
10.1124/JPET.108.145011
P407
P577
2008-10-17T00:00:00Z