Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities
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Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell DeathEnzymatic methods for glyco(diversification/randomization) of drugs and small moleculesAn Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased SafetyIt only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drugRecent progress in the study of the interactions of amphotericin B with cholesterol and ergosterol in lipid environments.Structure-antifungal activity relationships of polyene antibiotics of the amphotericin B group.Identification of an aminothiazole with antifungal activity against intracellular Histoplasma capsulatum.Nontoxic antimicrobials that evade drug resistance.Amphotericin primarily kills yeast by simply binding ergosterol.Characterization of a Polyethylene Glycol-Amphotericin B Conjugate Loaded with Free AMB for Improved Antifungal Efficacy.Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.C3-OH of Amphotericin B Plays an Important Role in Ion ConductanceFrom synthesis to function via iterative assembly of N-methyliminodiacetic acid boronate building blocks.David and Goliath: chemical perturbation of eukaryotes by bacteria.The effect of sterols on amphotericin B self-aggregation in a lipid bilayer as revealed by free energy simulations.Application of isothermal titration calorimetry as a tool to study natural product interactions.Amphotericin B potentiates the anticancer activity of doxorubicin on the MCF-7 breast cancer cells.Fungicide Xylaria sp. BCC 1067 extract induces reactive oxygen species and activates multidrug resistance system in Saccharomyces cerevisiae.Transmembrane delivery of anticancer drugs through self-assembly of cyclic peptide nanotubes.Amphotericin forms an extramembranous and fungicidal sterol sponge.A brief history of antibiotics and select advances in their synthesis.Fungal fatal attraction: a mechanistic review on targeting liposomal amphotericin B (AmBisome®) to the fungal membrane.C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cellsElectronic tuning of site-selectivity.Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel.Batch to flow deoxygenation using visible light photoredox catalysis.Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.Late-stage chemoselective functional-group manipulation of bioactive natural products with super-electrophilic silylium ions.New Horizons in Antifungal Therapy.The Aspergillus fumigatus Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice.The Draft Genome Sequence of Actinokineospora bangkokensis 44EHWT Reveals the Biosynthetic Pathway of the Antifungal Thailandin Compounds with Unusual Butylmalonyl-CoA Extender Units.A new look at the antibiotic amphotericin B effect on Candida albicans plasma membrane permeability and cell viability functions.
P2860
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P2860
Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synthesis-enabled functional g ...... nnel and antifungal activities
@ast
Synthesis-enabled functional g ...... nnel and antifungal activities
@en
Synthesis-enabled functional g ...... nnel and antifungal activities
@nl
type
label
Synthesis-enabled functional g ...... nnel and antifungal activities
@ast
Synthesis-enabled functional g ...... nnel and antifungal activities
@en
Synthesis-enabled functional g ...... nnel and antifungal activities
@nl
prefLabel
Synthesis-enabled functional g ...... nnel and antifungal activities
@ast
Synthesis-enabled functional g ...... nnel and antifungal activities
@en
Synthesis-enabled functional g ...... nnel and antifungal activities
@nl
P2093
P2860
P356
P1476
Synthesis-enabled functional g ...... nnel and antifungal activities
@en
P2093
Brandon C Wilcock
Daniel S Palacios
David M Siebert
Ian Dailey
Martin D Burke
P2860
P304
P356
10.1073/PNAS.1015023108
P407
P577
2011-02-28T00:00:00Z