LKB1 preserves genome integrity by stimulating BRCA1 expression. - Wikidata - wikimedia - TriplyDB

LKB1 preserves genome integrity by stimulating BRCA1 expression.

LKB1 preserves genome integrity by stimulating BRCA1 expression.

http://www.wikidata.org/entity/Q34883396

about

LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.Hereditary breast and ovarian cancer: new genes in confined pathways.Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer.Loss of LKB1 Expression Decreases the Survival and Promotes Laryngeal Cancer Metastasis.The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168.Synergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers.Cytoplasmic liver kinase B1 promotes the growth of human lung adenocarcinoma by enhancing autophagy

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LKB1 preserves genome integrity by stimulating BRCA1 expression.

http://www.wikidata.org/entity/Q34883396

description

2014 nî lūn-bûn

@nan

2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@ast

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@en

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@nl

type

label

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@ast

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@en

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@nl

prefLabel

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@ast

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@en

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@nl

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Nucleic Acids Research

P1476

LKB1 preserves genome integrity by stimulating BRCA1 expression.

@en

P2093

Alex Y Liu

http://www.w3.org/2001/XMLSchema#string

Narendra Wajapeyee

http://www.w3.org/2001/XMLSchema#string

Romi Gupta

http://www.w3.org/2001/XMLSchema#string

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Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

The Hallmarks of Cancer

Cancer genome landscapes

Hallmarks of Cancer: The Next Generation

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

AMP-activated kinase regulates cytoplasmic HuR.

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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259-271

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scholarly article

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10.1093/NAR/GKU1294

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1

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43

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2014-12-08T00:00:00Z

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269413443

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25488815

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