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Gene-environment interactions in Parkinson's disease: the importance of animal modeling.

Gene-environment interactions in Parkinson's disease: the importance of animal modeling.

http://www.wikidata.org/entity/Q34898429

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Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunction The role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelism Gene-environment interactions: key to unraveling the mystery of Parkinson's disease Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells.Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.Oxidative stress, mitochondrial damage and neurodegenerative diseases Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease PET imaging a MPTP-induced mouse model of Parkinson's disease using the fluoropropyl-dihydrotetrabenazine analog [18F]-DTBZ (AV-133)Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases.Eryptosis as a marker of Parkinson's disease Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Susceptibility to a parkinsonian toxin varies during primate development Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria.Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease Glutaredoxin 1 protects dopaminergic cells by increased protein glutathionylation in experimental Parkinson's disease.Dopamine synthesis and D3 receptor activation in pancreatic β-cells regulates insulin secretion and intracellular [Ca(2+)] oscillations.Validation of hospital register-based diagnosis of Parkinson's disease.Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP⁺-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity Compartmentalized oxidative stress in dopaminergic cell death induced by pesticides and complex I inhibitors: distinct roles of superoxide anion and superoxide dismutases.Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.Oxidative stress in genetic mouse models of Parkinson's disease.Oxidative damage to macromolecules in human Parkinson disease and the rotenone model.The Proteasome Inhibition Model of Parkinson's Disease.Recent developments in circulating biomarkers in Parkinson's disease: the potential use of miRNAs in a clinical setting.Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients.Tetrahydroxystilbene glucoside inhibits α-synuclein aggregation and apoptosis in A53T α-synuclein-transfected cells exposed to MPP.Convergent pathways in Parkinson's disease.Regulation of complex I by Engrailed is complex too.

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Gene-environment interactions in Parkinson's disease: the importance of animal modeling.

http://www.wikidata.org/entity/Q34898429

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2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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Gene-environment interactions in Parkinson's disease: the importance of animal modeling.

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Gene-environment interactions in Parkinson's disease: the importance of animal modeling.

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

Parkinson's disease: from monogenic forms to genetic susceptibility factors

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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