Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].
about
Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingKDM1 class flavin-dependent protein lysine demethylasesHistone Demethylases in Colon Cancer.Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer.Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells.Lysine-specific demethylase 1 promotes tumorigenesis and predicts prognosis in gallbladder cancer.Downregulation of LSD1 suppresses the proliferation, tumorigenicity and invasion of papillary thyroid carcinoma K1 cells.LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMPIdentification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells.Advances toward LSD1 inhibitors for cancer therapy.TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.miR-329 suppresses the growth and motility of neuroblastoma by targeting KDM1A.Bax is involved in the anticancer activity of Velcade in colorectal cancer.LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene.Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5(+) liver cancer initiating cells by suppressing negative regulators of β-catenin signaling.New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells.Lsd1 interacts with cMyb to demethylate repressive histone marks and maintain inner ear progenitor identity.Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer.KDM1A microenvironment, its oncogenic potential, and therapeutic significance.
P2860
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P2860
Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Lysine-specific demethylase 1 ...... Dickkopf-1 (DKK1) [corrected].
@ast
Lysine-specific demethylase 1 ...... Dickkopf-1 (DKK1) [corrected].
@en
type
label
Lysine-specific demethylase 1 ...... Dickkopf-1 (DKK1) [corrected].
@ast
Lysine-specific demethylase 1 ...... Dickkopf-1 (DKK1) [corrected].
@en
prefLabel
Lysine-specific demethylase 1 ...... Dickkopf-1 (DKK1) [corrected].
@ast
Lysine-specific demethylase 1 ...... Dickkopf-1 (DKK1) [corrected].
@en
P2093
P2860
P1433
P1476
Lysine-specific demethylase 1 ...... Dickkopf-1 (DKK1) [corrected].
@en
P2093
Linfang Wang
Qinshan Li
Shangze Li
Shiying Miao
Xiaodong Zhang
Yongqing Han
Zebin Huang
P2860
P304
P356
10.1371/JOURNAL.PONE.0070077
P407
P577
2013-07-26T00:00:00Z