Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice. - Wikidata - wikimedia - TriplyDB

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

http://www.wikidata.org/entity/Q34909750

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Definition of a molecular pathway mediating α-synuclein neurotoxicity α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation Disease-modifying therapeutic directions for Lewy-Body dementias The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Alpha-synuclein biology in Lewy body diseases Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe.Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.The Synaptic Function of α-Synuclein Alpha-synuclein spreading in Parkinson's disease Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.Whole-brain 3D mapping of human neural transplant innervation.Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Pathological alpha-synuclein propagates through neural networks Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot.The role of Galectin-3 in α-synuclein-induced microglial activation.Alpha-synuclein transfers from neurons to oligodendrocytes.Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.Progression of Seed-Induced Aβ Deposition within the Limbic Connectome Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons.α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Structural and functional properties of prefibrillar α-synuclein oligomers An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff.The pathomechanisms underlying Parkinson's disease.Olfactory bulb involvement in neurodegenerative diseases.Potential of Cellular and Animal Models Based on a Prion-Like Propagation of α-Synuclein for Assessing Antiparkinson Agents.Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice.Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Neuropathology of α-synuclein propagation and braak hypothesis.Alpha-synuclein propagation: New insights from animal models.

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Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

http://www.wikidata.org/entity/Q34909750

description

2013 nî lūn-bûn

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2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2013 թվականի օգոստոսին հրատարակված գիտական հոդված

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2013年の論文

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name

Transfer of human α-synuclein ...... nnected brain regions in mice.

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Transfer of human α-synuclein ...... nnected brain regions in mice.

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Transfer of human α-synuclein ...... nnected brain regions in mice.

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type

label

Transfer of human α-synuclein ...... nnected brain regions in mice.

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Transfer of human α-synuclein ...... nnected brain regions in mice.

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Transfer of human α-synuclein ...... nnected brain regions in mice.

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Transfer of human α-synuclein ...... nnected brain regions in mice.

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Transfer of human α-synuclein ...... nnected brain regions in mice.

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Transfer of human α-synuclein ...... nnected brain regions in mice.

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Acta Neuropathologica

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Transfer of human α-synuclein ...... nnected brain regions in mice.

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Geraldine H Petit

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Luc Bousset

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Nolwen L Rey

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Ronald Melki

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P2860

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

Alpha-synuclein in Lewy bodies

Staging of brain pathology related to sporadic Parkinson's disease

Alpha-synuclein and neurodegenerative diseases

Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration

Axonal transport defects: a common theme in neurodegenerative diseases

Stages in the development of Parkinson's disease-related pathology

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

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