Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.
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Definition of a molecular pathway mediating α-synuclein neurotoxicityα-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formationDisease-modifying therapeutic directions for Lewy-Body dementiasThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseAlpha-synuclein biology in Lewy body diseasesTransmission of α-synucleinopathy from olfactory structures deep into the temporal lobe.Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.The Synaptic Function of α-SynucleinAlpha-synuclein spreading in Parkinson's diseaseIntramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.Whole-brain 3D mapping of human neural transplant innervation.Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Pathological alpha-synuclein propagates through neural networksProtease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot.The role of Galectin-3 in α-synuclein-induced microglial activation.Alpha-synuclein transfers from neurons to oligodendrocytes.Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injuryDirect evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.Progression of Seed-Induced Aβ Deposition within the Limbic ConnectomeDistribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons.α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradientPrion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Structural and functional properties of prefibrillar α-synuclein oligomersAn Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's diseaseAnti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff.The pathomechanisms underlying Parkinson's disease.Olfactory bulb involvement in neurodegenerative diseases.Potential of Cellular and Animal Models Based on a Prion-Like Propagation of α-Synuclein for Assessing Antiparkinson Agents.Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice.Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like PropagationPrions and Protein Assemblies that Convey Biological Information in Health and Disease.Neuropathology of α-synuclein propagation and braak hypothesis.Alpha-synuclein propagation: New insights from animal models.
P2860
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P2860
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Transfer of human α-synuclein ...... nnected brain regions in mice.
@ast
Transfer of human α-synuclein ...... nnected brain regions in mice.
@en
Transfer of human α-synuclein ...... nnected brain regions in mice.
@nl
type
label
Transfer of human α-synuclein ...... nnected brain regions in mice.
@ast
Transfer of human α-synuclein ...... nnected brain regions in mice.
@en
Transfer of human α-synuclein ...... nnected brain regions in mice.
@nl
prefLabel
Transfer of human α-synuclein ...... nnected brain regions in mice.
@ast
Transfer of human α-synuclein ...... nnected brain regions in mice.
@en
Transfer of human α-synuclein ...... nnected brain regions in mice.
@nl
P2093
P2860
P1476
Transfer of human α-synuclein ...... nnected brain regions in mice.
@en
P2093
Geraldine H Petit
Luc Bousset
Nolwen L Rey
Ronald Melki
P2860
P2888
P304
P356
10.1007/S00401-013-1160-3
P577
2013-08-08T00:00:00Z