Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease.
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The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementiaParkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-14-Hydroxy-nonenal-A Bioactive Lipid Peroxidation ProductIs Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson's Disease?Redox regulation of T-cell function: from molecular mechanisms to significance in human health and diseaseBiophysical characterization of α-synuclein and its controversial structureA53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old miceVesicular integrity in Parkinson's diseaseBiology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorderAlpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells"Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system.At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillationα-Synuclein-induced tubule formation in lipid bilayersEffect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation.Dopamine transporter trafficking: rapid response on demand.Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans.Alpha-synuclein is a cellular ferrireductase.Variants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample.Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.Role of oxidative stress in Parkinson's disease.Structure of membrane-bound alpha-synuclein studied by site-directed spin labelingOxidative damage to RNA: mechanisms, consequences, and diseases.Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregationQuantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopyAlpha-synuclein function and dysfunction on cellular membranes.Alterations in energy metabolism, neuroprotection and visual signal transduction in the retina of Parkinsonian, MPTP-treated monkeysElevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.Presynaptic effects of levodopa and their possible role in dyskinesia.The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axonsOxidative stress in neurodegenerative diseases.Proteomics in neurodegenerative diseases: Methods for obtaining a closer look at the neuronal proteome.Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons.Polymorphism in the Vesicular Monoamine Transporter 2 Gene Decreases the Risk of Parkinson's Disease in Han Chinese Men.Alpha synuclein gene expression profile in the retina of vertebratesSilencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells.Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopyOxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options.Antioxidant gene therapy against neuronal cell death.Protein homeostasis and aging in neurodegeneration.
P2860
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P2860
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@ast
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@en
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@nl
type
label
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@ast
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@en
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@nl
prefLabel
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@ast
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@en
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@nl
P921
P356
P1476
Impaired dopamine storage resu ...... enesis of Parkinson's disease.
@en
P2093
Julie Lotharius
P304
P356
10.1093/HMG/11.20.2395
P577
2002-10-01T00:00:00Z