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Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

http://www.wikidata.org/entity/Q34918986

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On the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndrome Prospects for Improving Brain Function in Individuals with Down Syndrome Emerging pharmacotherapies for neurodevelopmental disorders Dissecting Alzheimer disease in Down syndrome using mouse models Timing of therapies for Down syndrome: the sooner, the better Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations.Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).Molecular basis of pharmacotherapies for cognition in Down syndrome Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome.Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome.Vitamin E inadequacy in humans: causes and consequences.Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.Targets for AD treatment: conflicting messages from γ-secretase inhibitors Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD).Designer receptors enhance memory in a mouse model of Down syndrome.Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome.Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia.The use of mouse models for understanding the biology of down syndrome and aging Age-related neurodegeneration and memory loss in down syndrome.Plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice.Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome.Antioxidants in Down syndrome.Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.Nerve growth factor metabolic dysfunction in Down's syndrome brains.Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice.A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model.Is it possible to improve neurodevelopmental abnormalities in Down syndrome?Strategies for the discovery of anti-aging compounds.Nutrition, adult hippocampal neurogenesis and mental health.Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome.Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome.Apoptosis in Down's syndrome: lessons from studies of human and mouse models.

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Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

http://www.wikidata.org/entity/Q34918986

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J.EXPNEUROL.2008.11.021

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Experimental Neurology

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Cholinergic degeneration and m ...... n a Down syndrome mouse model.

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Ann-Charlotte Granholm

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Annamalai Prakasam

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Heather Bimonte-Nelson

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Jason Lockrow

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Kumar Sambamurti

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Peng Huang

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P2860

Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator

Cholinergic innervation of parvalbumin- and calbindin-containing neurones in the hippocampus during postnatal development of the rat brain.

Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease.

Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.

Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome.

Vitamin E and donepezil for the treatment of mild cognitive impairment.

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.

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278-289

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10.1016/J.EXPNEUROL.2008.11.021

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19135442

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