An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3
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Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of lifeFatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological AdvancesThe fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissuesDiet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake.Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fishVertebrate fatty acyl desaturase with Δ4 activityRelationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids.Elongase reactions as control points in long-chain polyunsaturated fatty acid synthesis.Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebratesSoraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.Alternative transcripts of fatty acid desaturase (FADS) genesLoss of FADS2 function severely impairs the use of HeLa cells as an in vitro model for host response studies involving fatty acid effectsFADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain.DNA methylation perturbations in genes involved in polyunsaturated Fatty Acid biosynthesis associated with depression and suicide riskThe fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells.Sustainable production of housefly (Musca domestica) larvae as a protein-rich feed ingredient by utilizing cattle manure.Omega-3 fatty acid supplementation and cardiovascular disease.Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture.A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis.Cytochrome b₅ coexpression increases Tetrahymena thermophila Δ6 fatty acid desaturase activity in Saccharomyces cerevisiae.Deep sequencing of the transcriptome reveals inflammatory features of porcine visceral adipose tissue.Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic AcidDietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets.Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration.Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells.Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing.Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health.Dietary essential α-linolenic acid and linoleic acid differentially modulate TNFα-induced NFκB activity in FADS2-deficient HEK-293 cells.Alternative splicing generates a novel FADS2 alternative transcript in baboons.Cloning and functional identification of delta5 fatty acid desaturase gene and its 5'-upstream region from marine fungus Thraustochytrium sp. FJN-10.Retention of n-3 polyunsaturated fatty acids in trimmed loin and belly is independent of timing of feeding ground flaxseed to growing-finishing female pigs.Dietary arachidonate differentially alters desaturase-elongase pathway flux and gene expression in liver and intestine of suckling pigs.Whole-body retention of α-linolenic acid and its apparent conversion to other n-3 PUFA in growing pigs are reduced with the duration of feeding α-linolenic acid.Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases.Fads3 modulates docosahexaenoic acid in liver and brain.Improved eicosapentaenoic acid production in Pythium splendens RBB-5 based on metabolic regulation analysis.
P2860
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P2860
An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@ast
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@en
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@nl
type
label
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@ast
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@en
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@nl
prefLabel
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@ast
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@en
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@nl
P2093
P2860
P1476
An alternate pathway to long-c ...... esaturates 20:2n-6 and 20:3n-3
@en
P2093
Cynthia Tyburczy
J Thomas Brenna
Kumar S D Kothapalli
Peter Lawrence
Woo Jung Park
P2860
P304
P356
10.1194/JLR.M800630-JLR200
P577
2009-02-06T00:00:00Z