A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.
about
Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discoveryExpanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cellsGeneration and characterisation of Friedreich ataxia YG8R mouse fibroblast and neural stem cell modelsPharmacological treatments for Friedreich ataxia.R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.Genome-Engineering Tools to Establish Accurate Reporter Cell Lines That Enable Identification of Therapeutic Strategies to Treat Friedreich's Ataxia.The infectious BAC genomic DNA expression library: a high capacity vector system for functional genomicsReversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor.Epigenetic-based therapies for Friedreich ataxia.Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.Synthetic transcription elongation factors license transcription across repressive chromatin.Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming.
P2860
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P2860
A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@ast
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@en
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@nl
type
label
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@ast
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@en
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@nl
prefLabel
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@ast
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@en
A GAA repeat expansion reporte ...... ning of therapeutic compounds.
@nl
P2093
P2860
P356
P1476
A GAA repeat expansion reporte ...... ening of therapeutic compounds
@en
P2093
Ana M Silva
Andrea H Németh
Angela J Russell
Javier Alegre-Abarrategui
Michele M P Lufino
P2860
P304
P356
10.1093/HMG/DDT370
P577
2013-08-13T00:00:00Z