A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
about
Insulin-secreting β cells require a post-genomic conceptRecent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem CellsKnowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own HandsStem Cells and Regenerative Medicine: Myth or Reality of the 21th CenturyHistone Deacetylases and Cardiometabolic DiseasesAdvances and challenges in the differentiation of pluripotent stem cells into pancreatic β cellsProteins and small molecules for cellular regenerative medicinePancreatic stem cells remain unresolvedConcise review: A chemical approach to control cell fate and functionPluripotent stem cells in regenerative medicine: challenges and recent progressConcise review: pancreas regeneration: recent advances and perspectivesSmall molecule-driven direct conversion of human pluripotent stem cells into functional osteoblastsUnlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axisA stem cell-based tool for small molecule screening in adipogenesisModulation of the pentose phosphate pathway induces endodermal differentiation in embryonic stem cellsEfficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methodsSkin fibroblasts from patients with type 1 diabetes (T1D) can be chemically transdifferentiated into insulin-expressing clusters: a transgene-free approachSmall-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouseDirected differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitorsHuman pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.High content screening for modulators of cardiac differentiation in human pluripotent stem cellsChemical approaches to stem cell biology and therapeuticsFunctional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation.Stem cell biology and drug discovery.A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators.High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type glutamate receptors.Embryonic stem cell application in drug discovery.Controlling destiny through chemistry: small-molecule regulators of cell fate.Total syntheses of indolactam alkaloids (-)-indolactam V, (-)-pendolmycin, (-)-lyngbyatoxin A, and (-)-teleocidin A-2.A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.Bioinspired materials for controlling stem cell fate.Current status of islet cell replacement and regeneration therapy.Stem Cell Therapy: A New Treatment for Burns?Recent advances in pancreas development: from embryonic pathways to programming renewable sources of beta cellsHuman pluripotent stem cell differentiation to functional pancreatic cells for diabetes therapies: Innovations, challenges and future directions.Switching of mesodermal and endodermal properties in hTERT-modified and expanded fetal human pancreatic progenitor cells.Regenerative chemical biology: current challenges and future potentialA screen for regulators of survival of motor neuron protein levelsGlial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and beta-cell proliferation in the developing mouse pancreas.
P2860
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P2860
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@ast
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@en
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@nl
type
label
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@ast
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@en
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@nl
prefLabel
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@ast
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@en
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
@nl
P2093
P356
P1476
A small molecule that directs differentiation of human ESCs into the pancreatic lineage
@en
P2093
Douglas Melton
Julia L Fox
Kelvin Lam
Kenji Osafune
Lance Davidow
Lee F Peng
Malgorzata Borowiak
René Maehr
Shuibing Chen
Stuart L Schreiber
P2888
P304
P356
10.1038/NCHEMBIO.154
P50
P577
2009-03-15T00:00:00Z