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Polycystin-1 regulates STAT activity by a dual mechanism

Polycystin-1 regulates STAT activity by a dual mechanism

http://www.wikidata.org/entity/Q34977988

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Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein Regulation of STATs by polycystin-1 and their role in polycystic kidney disease Polycystin-1 cleavage and the regulation of transcriptional pathways A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8 The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.Kidney: polycystic kidney disease.Antisense-mediated angiotensinogen inhibition slows polycystic kidney disease in mice with a targeted mutation in Pkd2 Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease.Molecular pathways and therapies in autosomal-dominant polycystic kidney disease Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease Vasopressin and disruption of calcium signalling in polycystic kidney disease.Regulation of Polycystin-1 Function by Calmodulin Binding.How insights from cardiovascular developmental biology have impacted the care of infants and children with congenital heart disease.STAT3 Signaling in Polycystic Kidney Disease The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions.Folate-conjugated rapamycin slows progression of polycystic kidney disease STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke.Androgen-STAT3 activation may contribute to gender disparity in human simply renal cysts Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease Polycystic kidney disease in 2011: Connecting the dots toward a polycystic kidney disease therapy.New treatments for autosomal dominant polycystic kidney disease Strategies targeting cAMP signaling in the treatment of polycystic kidney disease.JAK inhibition and progressive kidney disease.Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis.The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1.Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling.Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context.Inflammation and Fibrosis in ADPKD.Primary Cilia in Cystic Kidney Disease.On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.Emerging Therapies for Childhood Polycystic Kidney Disease.Polycystin and calcium signaling in cell death and survival.Src family kinases in chronic kidney disease.The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism.Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.Extracellular Signal-Regulated Kinase 1/2 Regulates Mouse Kidney Injury Molecule-1 Expression Physiologically and Following Ischemic and Septic Renal Injury.Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease.Soluble syntaxin 3 functions as a transcriptional regulator.Unique interstitial miRNA signature drives fibrosis in a murine model of autosomal dominant polycystic kidney disease

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Polycystin-1 regulates STAT activity by a dual mechanism

http://www.wikidata.org/entity/Q34977988

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2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Polycystin-1 regulates STAT activity by a dual mechanism

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Jeffrey J Talbot

http://www.w3.org/2001/XMLSchema#string

Jonathan M Shillingford

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Nicholas Doerr

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Sambuddho Mukherjee

http://www.w3.org/2001/XMLSchema#string

Shivakumar Vasanth

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Terry Watnick

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P2860

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

The STATs of cancer--new molecular targets come of age

Advances in the pathogenesis and treatment of polycystic kidney disease

Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.

Polycystic kidney disease.

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