Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis.
about
Identification of novel functional inhibitors of acid sphingomyelinaseRole of Sphingolipids in the Pathobiology of Lung InflammationInhibition of acid sphingomyelinase by tricyclic antidepressants and analogonsAcid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD.Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repairAdjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial InfectionsAnti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis.High dose sertraline monotherapy fails to protect rhesus macaques from lethal challenge with Ebola virus Makona.A high-throughput sphingomyelinase assay using natural substrate.Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthaseAcid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury.Protein histidine [de]phosphorylation in insulin secretion: abnormalities in models of impaired insulin secretion.Acid sphingomyelinase gene deficiency ameliorates the hyperhomocysteinemia-induced glomerular injury in mice.Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).Crystal structure of mammalian acid sphingomyelinaseCeramides: a potential therapeutic target in pulmonary emphysema.Sphingolipids Are Dual Specific Drug Targets for the Management of Pulmonary Infections: Perspective.Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.Update in cystic fibrosis 2010.Lipids in cystic fibrosis.The role of sphingolipids in respiratory disease.Functional Rescue of F508del-CFTR Using Small Molecule CorrectorsIon channels in regulated cell death.Targeting sphingosine-1-phosphate signaling in lung diseases.Cystic fibrosis: a clinical view.Lipid raft-dependent activation of dual oxidase 1/H2O2/NF-κB pathway in bronchial epithelial cells.Ceramide mediates lung fibrosis in cystic fibrosis.The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis.Ceramide in cystic fibrosis: a potential new target for therapeutic intervention.Fluoxetine induced suicidal erythrocyte death.Antidepressant drug, desipramine, alleviates allergic rhinitis by regulating Treg and Th17 cells.Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide.Sphingosine rescues aged mice from pulmonary pseudomonas infection.Ceramides in tracheal aspirates of preterm infants: Marker for bronchopulmonary dysplasia.Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells.Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931.
P2860
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P2860
Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@ast
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@en
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@nl
type
label
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@ast
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@en
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@nl
prefLabel
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@ast
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@en
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@nl
P2093
P2860
P50
P356
P1476
Acid sphingomyelinase inhibito ...... flammation in cystic fibrosis.
@en
P2093
Gerd Döring
Joachim Riethmüller
P2860
P304
P356
10.1165/RCMB.2009-0174OC
P577
2009-07-27T00:00:00Z