Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. - Wikidata - wikimedia - TriplyDB

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

http://www.wikidata.org/entity/Q35005794

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Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance Charcot-Marie-Tooth disease and intracellular traffic Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders Therapeutic neuroprotective agents for amyotrophic lateral sclerosis PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking.Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?The Sac domain-containing phosphoinositide phosphatases: structure, function, and disease Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.The role of PI3P phosphatases in the regulation of autophagy Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3 Distinct pathogenic processes between Fig4-deficient motor and sensory neurons.Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P₂ phosphatase FIG4.Integration of clearance mechanisms: the proteasome and autophagy.Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy.Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments.Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines.Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.Computational model for autophagic vesicle dynamics in single cells.Minocycline induces protective autophagy in vascular endothelial cells exposed to an in vitro model of ischemia/reperfusion-induced injury.Fig4 deficiency: a newly emerged lysosomal storage disorder?The role of lipids in the control of autophagy Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4.A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis

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P2860

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

http://www.wikidata.org/entity/Q35005794

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

@ast

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

@en

type

label

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

@ast

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

@en

prefLabel

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

@ast

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

@en

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Human Molecular Genetics

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Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

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Cole J Ferguson

http://www.w3.org/2001/XMLSchema#string

Guy M Lenk

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Miriam H Meisler

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

A conserved sorting-associated protein is mutant in chorea-acanthocytosis

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.

The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

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10.1093/HMG/DDP460

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24

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