Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis
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Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative DiseasesAcid-sensing ion channels in pain and disease.Structure and activity of the acid-sensing ion channelsTwo aspects of ASIC function: Synaptic plasticity and neuronal injury.Physiological and pathological functions of acid-sensing ion channels in the central nervous system.The Concise Guide to PHARMACOLOGY 2013/14: ion channelsDoes closure of acid-sensing ion channels reduce ischemia/reperfusion injury in the rat brain?Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulationAcidosis, acid-sensing ion channels, and neuronal cell death.Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction.Acid-sensing ion channels: trafficking and synaptic function.The pharmacology and therapeutic potential of small molecule inhibitors of acid-sensing ion channels in stroke interventionMolecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death.Polyamines and programmed cell death.ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domainHeteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal deathPolyamines in aging and diseaseAcid-sensing ion channels: potential therapeutic targets for neurologic diseases.N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling.Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling.Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injuryTissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction.Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insultsAcid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanismsThe Thumb Domain Mediates Acid-sensing Ion Channel Desensitization.Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal deathAstrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Chronic EpileptogenesisCerebral Microvascular Endothelial Cell Apoptosis after Ischemia: Role of Enolase-Phosphatase 1 Activation and Aci-Reductone Dioxygenase 1 Translocation.Independent contribution of extracellular proton binding sites to ASIC1a activation.Polyamines as Snake Toxins and Their Probable Pharmacological Functions in Envenomation.Bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel (ASIC1a).Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential.Proton production, regulation and pathophysiological roles in the mammalian brainAcid-sensing ion channels in pathological conditions.Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?The CNS under pathophysiologic attack--examining the role of K₂p channels.ASICs and neuropeptides.Non-NMDAR neuronal Ca(2+)-permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage.Regulating Factors in Acid-Sensing Ion Channel 1a Function.Acidity and Acid-Sensing Ion Channels in the Normal and Alzheimer's Disease Brain.
P2860
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P2860
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2011 թվականի փետրվարին հրատարակված գիտական հոդված
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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name
Extracellular spermine exacerb ...... nels to extracellular acidosis
@ast
Extracellular spermine exacerb ...... nels to extracellular acidosis
@en
type
label
Extracellular spermine exacerb ...... nels to extracellular acidosis
@ast
Extracellular spermine exacerb ...... nels to extracellular acidosis
@en
prefLabel
Extracellular spermine exacerb ...... nels to extracellular acidosis
@ast
Extracellular spermine exacerb ...... nels to extracellular acidosis
@en
P2093
P2860
P1476
Extracellular spermine exacerb ...... nels to extracellular acidosis
@en
P2093
Jillian Hansen
Michael X Zhu
Roger P Simon
Tian-Le Xu
Yi-Zhi Wang
Zhi-Gang Xiong
P2860
P304
P356
10.1523/JNEUROSCI.4351-10.2011
P407
P577
2011-02-01T00:00:00Z