mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation. - Wikidata - wikimedia - TriplyDB

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

http://www.wikidata.org/entity/Q35007765

about

The Function of Autophagy in Neurodegenerative Diseases BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.Electroacupuncture protects against ischemic stroke by reducing autophagosome formation and inhibiting autophagy through the mTORC1-ULK1 complex-Beclin1 pathway.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.An expanded role for mTORC1 in autophagy.Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy.The Drosophila Accessory Gland as a Model for Prostate Cancer and Other Pathologies.Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects.Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice.The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.Autophagy and Alzheimer's Disease.Fine-tuning autophagy: from transcriptional to posttranslational regulation.mTORC1 signaling and the metabolic control of cell growth.Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response.mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.Investigation and intervention of autophagy to guide cancer treatment with nanogels.ZMP: a master regulator of one-carbon metabolism.mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.Autophagy in Measles Virus Infection.MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex.mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks.Rubicon: LC3-associated phagocytosis and beyond.Central neurotoxicity induced by the instillation of ZnO and TiO2 nanoparticles through the taste nerve pathway.Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy.A Molecular Perspective of Mammalian Autophagosome Biogenesis.Autophagic Flux is Regulated by Interaction Between the C-terminal Domain of Patched1 and ATG101.Macroautophagy and Chaperone-Mediated Autophagy in Heart Failure: The Known and the Unknown.Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast.Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking.Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice AMPK contributes to autophagosome maturation and lysosomal fusion

P2860

Q26777018-A258E3AA-710D-49F4-980E-4E0741C831FC Q36379709-56EF12B8-9EC7-4668-8864-3CD86363F621 Q36473735-9C3AC4E5-212D-45DD-B464-BC8036784607 Q36712621-A2B00FC8-136E-4567-98D8-084B2E818D15 Q36836101-37A570F5-6E39-4BC2-80A6-48C233376831 Q37126857-D3F10898-181C-4774-8DE6-A05601F6A9F3 Q37291277-135C8ADD-DF34-4185-A24D-F13B87958105 Q37577716-7AAA4236-757C-4856-B42B-14ECBEA65899 Q38689955-A45A8C32-64EE-42C1-A630-7D447CFD25B0 Q38735257-211070C5-334C-4F92-8DA6-65A28F1DBF06 Q38780596-EEB9FF2B-6C1B-47E0-B2AF-306EF29A64ED Q38853431-6895AA1A-7FEE-4C09-97CD-589579D949DC Q38874018-100D32EA-862B-4BDD-ADB5-F696DFBD8660 Q39243905-1D483916-036C-4A97-877E-2A274EEAF097 Q40084069-A3C40BF8-BFB0-4A14-8FC6-E1F656609ECD Q40771740-0D05FB10-2C94-4EBF-8F13-2F8230619A92 Q41831125-0B318565-7DF4-42AE-9135-3E1C159D02A0 Q41913812-0046B616-270F-4C04-8727-C33EDB1C940F Q41972877-F9331566-3C0A-4A81-9945-69A41563D3C8 Q42509388-11DF2272-D923-4B84-9E3C-3F158C849DA1 Q45324093-D03B12AB-AF92-47BD-9391-CF30A0407A2E Q46563880-4B3F4861-A431-40C3-901C-7790222F55F6 Q46898755-78C7B3FF-C9E8-4F77-8D11-82321ADC808B Q47149655-A601325E-46C3-4597-842F-854C2D4B6D57 Q47219778-70E60595-8683-4DB8-B923-BF306FED25D2 Q47390421-E04EF1C6-65A9-4E09-B0F9-B15A278BF5C8 Q47568393-18413123-CAB8-4C90-B88D-0F6954776E5A Q47859436-3A444742-2924-4F37-8798-1F6198F55AB0 Q47964526-53C73DFE-4BF9-4E65-A1B4-CC8A04A80014 Q48163587-AFA487D5-AD5D-45E7-A643-3F4E560650F1 Q49913662-613540DF-51CE-4BC6-BC76-3781189827CC Q52632550-3D030DE7-E560-4200-8382-9C63BEE51B35 Q52723495-253F4F42-90CA-4F80-B959-17065A803A14 Q55312015-9229B0CD-2877-48FE-A080-D31F75C18F40 Q57805803-41151ADD-7326-4F42-9E4B-2495B63F9550 Q58714265-E11CF56D-8443-4E6B-8356-E04EF57B0753

P2860

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

http://www.wikidata.org/entity/Q35007765

description

2014 nî lūn-bûn

@nan

2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

@ast

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

@en

type

label

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

@ast

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

@en

prefLabel

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

@ast

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

@en

P1433

Q35007765-C9153514-CA6D-4829-B493-B74FE28CDB32

P1476

Q35007765-7F6FFE6C-A428-4912-B92B-3D7A8B6F4F5B

P2093

Q35007765-1316BCCB-17F5-4987-9272-BB689C0AB7CD

Q35007765-3689BB40-9CF6-427B-AD8F-49E4381C3B71

Q35007765-3A5B883C-F777-4906-B740-E379059EE888

Q35007765-4D75999C-2114-4042-9CB6-718219E1377E

Q35007765-9629CF45-9317-46AA-99C4-680DA2CBB91B

Q35007765-AD4CD84E-1B94-483F-9FF1-16443171D346

P2860

Q35007765-0CCF6D97-1C29-4C63-B415-CFE611AE1245

Q35007765-0F9EE7A4-8410-4377-81A7-48BB1CAA38EE

Q35007765-121539A3-1A64-4614-927A-991A05F9FEF0

Q35007765-18ED7F10-217F-41B8-AF40-19A94668845E

Q35007765-1AE160EA-6DEA-449D-9E06-3424E234732B

Q35007765-1C3B49AC-4F7C-44ED-A1B2-D11C909EA620

Q35007765-1E29B81D-5D8D-4C9C-90BD-DCED97A0A45A

Q35007765-1E31331B-3DD2-47A3-83D7-C0779B0A341F

Q35007765-217018D4-CAE7-40ED-ABDD-B4A9442380F3

Q35007765-26E2BD49-95D9-4E96-BCC8-DBE9D83626C5

P304

Q35007765-4A3083CF-9974-446E-9367-8D20674BC237

P31

Q35007765-C4856B9E-5A7D-4636-BA90-AD288E15F8A2

P356

Q35007765-C1605232-7177-4AFF-B5B5-EB2125C23E0F

P433

Q35007765-A9AFD41E-7EBD-48EE-9C1A-89DDF1BBB907

P478

Q35007765-63032656-DB0B-4A88-ADCB-B3F460274117

P50

Q35007765-E4FF1DF3-BD87-4FDF-AAD4-0304C8A3B01E

P577

Q35007765-03989D0C-4D79-46C4-8D02-2C80103B59EE

P698

Q35007765-8048E6A4-9E0E-4952-AF93-A1B0D1B65AEE

P921

Q35007765-4E0DB048-A561-4048-AD5B-02ED7DDB4E20

Q35007765-9542D222-E125-474C-BB4F-8F21F98913BE

P932

Q35007765-F14B5369-A30B-4560-9435-647C2FE622A5

P356

J.MOLCEL.2014.11.013

P1433

P1476

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

@en

P2093

Chang Hwa Jung

http://www.w3.org/2001/XMLSchema#string

Eun Kyoung Kim

http://www.w3.org/2001/XMLSchema#string

Ji-Man Park

http://www.w3.org/2001/XMLSchema#string

Minchul Seo

http://www.w3.org/2001/XMLSchema#string

Sun Sik Bae

http://www.w3.org/2001/XMLSchema#string

Young-Mi Kim

http://www.w3.org/2001/XMLSchema#string

P2860

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion

The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

A dual role for UVRAG in maintaining chromosomal stability independent of autophagy

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17

P304

207-218

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.MOLCEL.2014.11.013

http://www.w3.org/2001/XMLSchema#string

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

57

http://www.w3.org/2001/XMLSchema#string

P50

P577

2014-12-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

25533187

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

4304967

http://www.w3.org/2001/XMLSchema#string