CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. - Wikidata - wikimedia - TriplyDB

CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis.

CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis.

http://www.wikidata.org/entity/Q35009699

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Post-translational modifications as key regulators of TNF-induced necroptosis Molecular crosstalk between apoptosis, necroptosis, and survival signaling Poly-ubiquitination in TNFR1-mediated necroptosis An outline of necrosome triggers The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways The two faces of receptor interacting protein kinase-1 Execution of RIPK3-regulated necrosis Role of necroptosis in the pathogenesis of solid organ injury Programmed necrosis in the cross talk of cell death and inflammation Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1 Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3 Necroptosis mediates TNF-induced toxicity of hippocampal neurons.Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death Necroptotic signaling in adaptive and innate immunity.RIP kinases: key decision makers in cell death and innate immunity.Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production.E2F1-regulated miR-30b suppresses Cyclophilin D and protects heart from ischemia/reperfusion injury and necrotic cell death CYLD-mediated signaling and diseases.The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death.Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome.Necroptosis: an alternative cell death program defending against cancer.RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.Necroptosis Is an Important Severity Determinant and Potential Therapeutic Target in Experimental Severe Pancreatitis.TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints.IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome.Necrosis-dependent and independent signaling of the RIP kinases in inflammation.Chemical regulation of signaling pathways to programmed necrosis.Staying alive: cell death in antiviral immunity.Harnessing of Programmed Necrosis for Fighting against Cancers.Programmed necrosis and necroptosis signalling.Emerging Roles for RIPK1 and RIPK3 in Pathogen-Induced Cell Death and Host Immunity.The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes.Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death.Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway.Necroptotic cell death in failing heart: relevance and proposed mechanisms.

P2860

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P2860

CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis.

http://www.wikidata.org/entity/Q35009699

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

CYLD deubiquitinates RIP1 in t ...... ation and programmed necrosis.

@ast

CYLD deubiquitinates RIP1 in t ...... ation and programmed necrosis.

@en

type

label

CYLD deubiquitinates RIP1 in t ...... ation and programmed necrosis.

@ast

CYLD deubiquitinates RIP1 in t ...... ation and programmed necrosis.

@en

prefLabel

CYLD deubiquitinates RIP1 in t ...... ation and programmed necrosis.

@ast

CYLD deubiquitinates RIP1 in t ...... ation and programmed necrosis.

@en

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JOURNAL.PONE.0076841

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CYLD deubiquitinates RIP1 in t ...... ation and programmed necrosis.

@en

P2093

David M Moquin

http://www.w3.org/2001/XMLSchema#string

Francis Ka-Ming Chan

http://www.w3.org/2001/XMLSchema#string

Thomas McQuade

http://www.w3.org/2001/XMLSchema#string

P2860

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

TNF-alpha induces two distinct caspase-8 activation pathways

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

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e76841

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scholarly article

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10.1371/JOURNAL.PONE.0076841

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10

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8

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