Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation.
about
Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia.A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease.Neuroprotective activity of stiripentol with a possible involvement of voltage-dependent calcium and sodium channels.Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.
P2860
Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Novel analogues of chlormethia ...... GABA(A) receptor potentiation.
@ast
Novel analogues of chlormethia ...... GABA(A) receptor potentiation.
@en
type
label
Novel analogues of chlormethia ...... GABA(A) receptor potentiation.
@ast
Novel analogues of chlormethia ...... GABA(A) receptor potentiation.
@en
prefLabel
Novel analogues of chlormethia ...... GABA(A) receptor potentiation.
@ast
Novel analogues of chlormethia ...... GABA(A) receptor potentiation.
@en
P2093
P2860
P356
P1476
Novel analogues of chlormethia ...... GABA(A) receptor potentiation.
@en
P2093
David R Pepperberg
Ehsan Tavassoli
Gregory R Thatcher
Lawren Vandevrede
Zhihui Qin
P2860
P304
P356
10.1111/BPH.12454
P407
P577
2014-01-01T00:00:00Z