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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

http://www.wikidata.org/entity/Q35021811

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The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor Differential gene regulation by the human and mouse aryl hydrocarbon receptor.Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand.Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.Intersection of AHR and Wnt signaling in development, health, and disease.Assessment of benzene-induced hematotoxicity using a human-like hematopoietic lineage in NOD/Shi-scid/IL-2Rγnull mice Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon receptor.Cytochrome P450 and xenobiotic receptor humanized mice.Polycyclic aromatic hydrocarbons: from metabolism to lung cancer.A mutant Ahr allele protects the embryonic kidney from hydrocarbon-induced deficits in fetal programming.Molecular targets that link dioxin exposure to toxicity phenotypes.Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet.Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity.Role of the aryl hydrocarbon receptor in drug metabolism.The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.A mouse strain less responsive to dioxin-induced prostaglandin E2 synthesis is resistant to the onset of neonatal hydronephrosis.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors.Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.Xenobiotic receptor humanized mice and their utility.The roles of aryl hydrocarbon receptor in immune responses.Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study.Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice.Transgenic Humanized AHR Mouse Reveals Differences between Human and Mouse AHR Ligand Selectivity.Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure.The mouse and human Ah receptor differ in recognition of LXXLL motifs.Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice.Regulatory interaction between arylhydrocarbon receptor and SIM1, two basic helix-loop-helix PAS proteins involved in the control of food intake.Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis.Toxicity of wood smoke particles in human A549 lung epithelial cells: the role of PAHs, soot and zinc.Aryl hydrocarbon receptor-based bioassays for dioxin detection: Thinking outside the box.From Classical Toxicology to Tox21: Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning From the Last Quarter of the 20th Century.Roles of cytosolic phospholipase A2α in reproductive and systemic toxicities in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed mice.Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.

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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

http://www.wikidata.org/entity/Q35021811

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2003 nî lūn-bûn

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2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2003 թվականի մայիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

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Proceedings of the National Academy of Sciences of the United States of America

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Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

@en

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Chiharu Tohyama

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Hozumi Motohashi

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Masayuki Yamamoto

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Noriko Nishimura

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Osamu Nakajima

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Satoru Takahashi

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Seiichiroh Ohsako

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Takashi Moriguchi

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Tomonori Hosoya

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Yasunobu Aoki

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P2860

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors

Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility

Cloning and expression of a human Ah receptor cDNA

cDNA cloning and structure of mouse putative Ah receptor

The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity

Cloning of a factor required for activity of the Ah (dioxin) receptor

The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resistant alleles to different rat lines

Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: greater insight into species differences in toxic potency of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain

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100

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