Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state
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Mechanisms of impaired differentiation in rhabdomyosarcomaHyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cellSMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma.p38α MAPK disables KMT1A-mediated repression of myogenic differentiation program.Small molecule inhibition of PAX3-FOXO1 through AKT activation suppresses malignant phenotypes of alveolar rhabdomyosarcomaHelicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.Epigenetic and epigenomic mechanisms shape sarcoma and other mesenchymal tumor pathogenesis.Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma.The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx).Stuck in a balancing act: histone methyltransferase activity of KMT1A traps alveolar rhabdomyosarcomas in an undifferentiated state.Acquisition of an oncogenic fusion protein is sufficient to globally alter the landscape of miRNA expression to inhibit myogenic differentiation.Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells.
P2860
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P2860
Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Histone methyltransferase KMT1 ...... myogenic differentiated state
@ast
Histone methyltransferase KMT1 ...... myogenic differentiated state
@en
type
label
Histone methyltransferase KMT1 ...... myogenic differentiated state
@ast
Histone methyltransferase KMT1 ...... myogenic differentiated state
@en
prefLabel
Histone methyltransferase KMT1 ...... myogenic differentiated state
@ast
Histone methyltransferase KMT1 ...... myogenic differentiated state
@en
P2093
P2860
P1433
P1476
Histone methyltransferase KMT1 ...... myogenic differentiated state
@en
P2093
Andrei V Gudkov
Asoke K Mal
Mathivanan Jothi
Min-Hyung Lee
P2860
P304
P356
10.1158/0008-5472.CAN-10-3358
P407
P577
2011-04-14T00:00:00Z