The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
about
The KSHV RNA regulator ORF57: target specificity and its role in the viral life cycleDeterminants and implications of mRNA poly(A) tail size--does this protein make my tail look big?Certain adenylated non-coding RNAs, including 5' leader sequences of primary microRNA transcripts, accumulate in mouse cells following depletion of the RNA helicase MTR4Alternative polyadenylation of mRNA precursors.Poly(A) tail length regulates PABPC1 expression to tune translation in the heart.Oculopharyngeal muscular dystrophy as a paradigm for muscle aging.Proteasome regulates the mediators of cytoplasmic polyadenylation signaling during late-phase long-term potentiation.Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions.Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesisSystematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation.HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolismInduced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signalingCanonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs.DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.Long noncoding RNAs: Re-writing dogmas of RNA processing and stability.Retention of hexanucleotide repeat-containing intron in C9orf72 mRNA: implications for the pathogenesis of ALS/FTDViral Evasion and Manipulation of Host RNA Quality Control Pathways.Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.PABPN1 gene therapy for oculopharyngeal muscular dystrophyStructure and function of pre-mRNA 5'-end capping quality control and 3'-end processing.New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA.CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα.Regulated Intron Retention and Nuclear Pre-mRNA Decay Contribute to PABPN1 AutoregulationPoly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs.The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation.Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner.Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing.Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export.Targeting the nuclear RNA exosome: Poly(A) binding proteins enter the stage.RNA surveillance by the nuclear RNA exosome: mechanisms and significance.The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts.Surveillance-ready transcription: nuclear RNA decay as a default fate.Diminished nuclear RNA decay upon infection upregulates antibacterial noncoding RNAsThe splicing factor SRSF3 is functionally connected to the nuclear RNA exosome for intronless mRNA decay
P2860
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P2860
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
@ast
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
@en
type
label
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
@ast
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
@en
prefLabel
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
@ast
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
@en
P2860
P1433
P1476
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
@en
P2093
Nicholas K Conrad
P2860
P304
P356
10.1371/JOURNAL.PGEN.1003893
P50
P577
2013-10-17T00:00:00Z