The charge structure of helix 1 in the prion protein regulates conversion to pathogenic PrPSc
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Mapping of possible prion protein self-interaction domains using peptide arraysThe intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions: a replica exchange molecular dynamics study.Prion protein misfolding.Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions.PrP charge structure encodes interdomain interactionsThe N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).A novel PRNP-P105S mutation associated with atypical prion disease and a rare PrPSc conformationCaprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells.Identifying key components of the PrPC-PrPSc replicative interface.Energy landscape of the prion protein helix 1 probed by metadynamics and NMR.Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteins.Molecular dynamics simulations of early steps in RNA-mediated conversion of prions.Structural and hydration properties of the partially unfolded states of the prion protein.Perturbations in inter-domain associations may trigger the onset of pathogenic transformations in PrP(C): insights from atomistic simulations.Conformation-dependent epitopes recognized by prion protein antibodies probed using mutational scanning and deep sequencing.Mutations Alter RNA-Mediated Conversion of Human Prions.
P2860
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P2860
The charge structure of helix 1 in the prion protein regulates conversion to pathogenic PrPSc
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
The charge structure of helix ...... conversion to pathogenic PrPSc
@ast
The charge structure of helix ...... conversion to pathogenic PrPSc
@en
type
label
The charge structure of helix ...... conversion to pathogenic PrPSc
@ast
The charge structure of helix ...... conversion to pathogenic PrPSc
@en
prefLabel
The charge structure of helix ...... conversion to pathogenic PrPSc
@ast
The charge structure of helix ...... conversion to pathogenic PrPSc
@en
P2860
P356
P1433
P1476
The charge structure of helix ...... conversion to pathogenic PrPSc
@en
P2093
Eric M Norstrom
James A Mastrianni
P2860
P304
P356
10.1128/JVI.00366-06
P407
P577
2006-09-01T00:00:00Z