about
Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesisPolyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynesStrain Prioritization and Genome Mining for Enediyne Natural ProductsImprovement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporusCharacterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistanceManipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027.Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.Glycosyloxyamine neoglycosylation: a model study using calicheamicin.Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis.Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluationComplete genome sequence of the filamentous gliding predatory bacterium Herpetosiphon aurantiacus type strain (114-95(T)).Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027Melting thermodynamics of reversible DNA/ligand complexes at interfaces.Characterization of CalE10, the N-oxidase involved in calicheamicin hydroxyaminosugar formationDraft genome sequence of Streptomyces sp. MWW064 for elucidating the rakicidin biosynthetic pathway.Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics.Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.PKS and NRPS release mechanisms.Microbial natural products: molecular blueprints for antitumor drugs.Iterative type I polyketide synthases involved in enediyne natural product biosynthesis.Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.Gemmata species: Planctomycetes of medical interest.The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes.Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis.Use of N-methylformamide as a solvent in indium-promoted Barbier reactions en route to enediyne and epoxy diyne formation: comparison of rate and stereoselectivity in C-C bond-forming reactions with water.Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.Secondary metabolism in the lichen symbiosis.The convergent evolution of defensive polyacetylenic fatty acid biosynthesis genes in soldier beetles.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Biosynthesis of enediyne antitumor antibiotics
@ast
Biosynthesis of enediyne antitumor antibiotics
@en
type
label
Biosynthesis of enediyne antitumor antibiotics
@ast
Biosynthesis of enediyne antitumor antibiotics
@en
prefLabel
Biosynthesis of enediyne antitumor antibiotics
@ast
Biosynthesis of enediyne antitumor antibiotics
@en
P2860
P1476
Biosynthesis of enediyne antitumor antibiotics
@en
P2093
Steven G Van Lanen
P2860
P304
P356
10.2174/156802608783955656
P577
2008-01-01T00:00:00Z