Role and timing of GTP binding and hydrolysis during EF-G-dependent tRNA translocation on the ribosome
about
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndromeThe three transfer RNAs occupying the A, P and E sites on the ribosome are involved in viral programmed -1 ribosomal frameshiftElongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-TuStructures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation.Structural basis for hygromycin B inhibition of protein biosynthesisVisualization of the eEF2–80S Ribosome Transition-State Complex by Cryo-Electron MicroscopySubstrate Binding in Protein-tyrosine Phosphatase-like Inositol PolyphosphatasesRibosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acidControl of Ribosomal Subunit Rotation by Elongation Factor GKinetics of the interactions between yeast elongation factors 1A and 1Balpha, guanine nucleotides, and aminoacyl-tRNA.Review: Translational GTPasesA monovalent cation acts as structural and catalytic cofactor in translational GTPasesThe process of mRNA-tRNA translocationNavigating the ribosome's metastable energy landscapeMolecular mechanics of 30S subunit head rotation.Following movement of domain IV of elongation factor G during ribosomal translocation.Ribosomal translocation: one step closer to the molecular mechanism.A SelB/EF-Tu/aIF2γ-like protein from Methanosarcina mazei in the GTP-bound form binds cysteinyl-tRNA(Cys.).Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2.Fusidic acid targets elongation factor G in several stages of translocation on the bacterial ribosome.A conserved histidine in switch-II of EF-G moderates release of inorganic phosphate.Dwell-Time Distribution, Long Pausing and Arrest of Single-Ribosome Translation through the mRNA DuplexIdentification of two distinct hybrid state intermediates on the ribosomeReal-time evidence for EF-G-induced dynamics of helix 44 in 16S rRNA.Cofactor dependent conformational switching of GTPases.The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form.The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G).Role of induced fit in enzyme specificity: a molecular forward/reverse switch.The ribosome returned.Coordinated conformational and compositional dynamics drive ribosome translocation.Similarity and diversity of translational GTPase factors EF-G, EF4, and BipA: From structure to functionProbing the mechanisms of translation with force.Reaction dynamics analysis of a reconstituted Escherichia coli protein translation system by computational modeling.Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis.Structural Insights into tRNA Dynamics on the Ribosome.Kinetics of nucleotide entry into RNA polymerase active site provides mechanism for efficiency and fidelity.Dual use of GTP hydrolysis by elongation factor G on the ribosome.Signal recognition particle (SRP) and SRP receptor: a new paradigm for multistate regulatory GTPases.GTPases IF2 and EF-G bind GDP and the SRL RNA in a mutually exclusive manner.Kinetically competent intermediates in the translocation step of protein synthesis.
P2860
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P2860
Role and timing of GTP binding and hydrolysis during EF-G-dependent tRNA translocation on the ribosome
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Role and timing of GTP binding ...... translocation on the ribosome
@ast
Role and timing of GTP binding ...... translocation on the ribosome
@en
type
label
Role and timing of GTP binding ...... translocation on the ribosome
@ast
Role and timing of GTP binding ...... translocation on the ribosome
@en
prefLabel
Role and timing of GTP binding ...... translocation on the ribosome
@ast
Role and timing of GTP binding ...... translocation on the ribosome
@en
P2860
P50
P356
P1476
Role and timing of GTP binding ...... translocation on the ribosome
@en
P2093
Berthold Wilden
P2860
P304
13670-13675
P356
10.1073/PNAS.0606099103
P407
P577
2006-08-29T00:00:00Z